Prenatal maternal immune activation increases anxiety- and depressive-like behaviors in offspring with experimental autoimmune encephalomyelitis

Neuroscience
J Majidi-ZolbaninA-A Salari

Abstract

Multiple sclerosis (MS) is thought to result from a combination of genetics and environmental factors. Several lines of evidence indicate that significant prevalence of anxiety and depression-related disorders in MS patients can influence the progression of the disease. Although we and others have already reported the consequences of prenatal maternal immune activation on anxiety and depression, less is known about the interplay between maternal inflammation, MS and gender. We here investigated the effects of maternal immune activation with Poly I:C during mid-gestation on the progression of clinical symptoms of experimental autoimmune encephalomyelitis (EAE; a mouse model of MS), and then anxiety- and depressive-like behaviors in non-EAE and EAE-induced offspring were evaluated. Stress-induced corticosterone and tumor necrosis factor-alpha (TNF-α) levels in EAE-induced offspring were also measured. Maternal immune activation increased anxiety and depression in male offspring, but not in females. This immune challenge also resulted in an earlier onset of the EAE clinical signs in male offspring and enhanced the severity of the disease in both male and female offspring. Interestingly, the severity of the disease was associated w...Continue Reading

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Citations

May 20, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ali-Akbar SalariJudith R Homberg
Oct 4, 2016·Current Behavioral Neuroscience Reports·Amanda Crider, Anilkumar Pillai
Oct 20, 2015·Current Problems in Pediatric and Adolescent Health Care·Amanda M Simanek, Helen C S Meier
Feb 16, 2019·Translational Psychiatry·Pierluca Coiro, Daniela D Pollak
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Jul 22, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jill M GoldsteinRobert J Handa
Aug 24, 2019·Neuroscience and Biobehavioral Reviews·Monokesh K SenPeter J Shortland
Aug 5, 2021·Experimental Physiology·Mohadeseh Gilak-DalasmMohammad Ali Azarbayjani
Jun 18, 2019·American Journal of Obstetrics and Gynecology·Benjamin J S Al-HaddadKristina M Adams Waldorf
Oct 24, 2018·Life Sciences·Morteza Kosari-NasabAli-Akbar Salari

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