Prenatal nicotinic exposure augments cardiorespiratory responses to activation of bronchopulmonary C-fibers

American Journal of Physiology. Lung Cellular and Molecular Physiology
Jianguo ZhuangFadi Xu

Abstract

Rat pups prenatally exposed to nicotine (PNE) present apneic (lethal ventilatory arrest) responses during severe hypoxia. To clarify whether these responses are of central origin, we tested PNE effects on ventilation and diaphragm electromyography (EMGdi) during hypoxia in conscious rat pups. PNE produced apnea (lethal ventilatory arrest) identical to EMGdi silencing during hypoxia, indicating a central origin of this apneic response. We further asked whether PNE would sensitize bronchopulmonary C-fibers (PCFs), a key player in generating central apnea, with increase of the density and transient receptor potential cation channel subfamily V member 1 (TRPV1) expression of C-fibers/neurons in the nodose/jugular (N/J) ganglia and neurotrophic factors in the airways and lungs. We compared 1) ventilatory and pulmonary C-neural responses to right atrial bolus injection of capsaicin (CAP, 0.5 μg/kg), 2) bronchial substance P-immunoreactive (SP-IR) fiber density, 3) gene and protein expressions of TRPV1 in the ganglia, and 4) nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) protein in bronchoalveolar lavage fluid (BALF) and TrkA and TrkB genes in the ganglia between control and PNE pups. PNE markedly strengthened ...Continue Reading

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Citations

Apr 17, 2016·Seminars in Immunopathology·Francesco De LoguPierangelo Geppetti
Jan 11, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jianguo ZhuangFadi Xu
Jun 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lei ZhaoFadi Xu
Jun 16, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiuping GaoFadi Xu
Oct 14, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rafal BartoszewskiJames F Collawn
Oct 17, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Wan WeiFadi Xu
Mar 20, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·P Padmini S J KhedoePieter S Hiemstra
Jul 22, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jianguo ZhuangFadi Xu
Aug 28, 2020·Frontiers in Neuroanatomy·Zhe ChenRong Dong
Oct 15, 2020·Physiology·Thomas E Taylor-Clark

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