Prenatal nitrate air pollution exposure and reduced child lung function: Timing and fetal sex effects.

Environmental Research
Sonali BoseRosalind J Wright

Abstract

Prenatal particulate air pollution exposure may alter lung growth and development in utero in a time-sensitive and sex-specific manner, resulting in reduced lung function in childhood. Such relationships have not been examined for nitrate (NO3-). We implemented Bayesian distributed lag interaction models (BDLIMs) to identify sensitive prenatal windows for the influence of NO3- on lung function at age 7 years, assessing effect modification by fetal sex. Analyses included 191 mother-child dyads. Daily ambient NO3- exposure over pregnancy was estimated using a hybrid chemical transport (Geos-Chem)/land-use regression model. Spirometry was performed at mean (SD) age of 6.99 (0.89) years, with forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) z-scores accounting for child age, sex, height and race/ethnicity. Most mothers were Hispanic (65%) or Black (22%), had ≤ high school education (67%), and never smoked (71%); 17% children had asthma. BDILMs adjusted for maternal age and education and child's asthma identified an early sensitive window of 6-12 weeks gestation, during which increased NO3- was significantly associated with reduced FEV1 z-scores specifically among boys. BDLIM analyses demonstrated simila...Continue Reading

Citations

Mar 19, 2019·Journal of Cellular Physiology·Zheng LiJianxiong Shen
Jan 17, 2020·Seminars in Immunopathology·Mahmoud I Abdel-AzizAnke H Maitland-van der Zee
Feb 3, 2021·Biostatistics·Daniel Mork, Ander Wilson
Nov 21, 2020·Environmental Research·Azahara M García-SernaUNKNOWN NELA Study group
Sep 30, 2021·American Journal of Respiratory and Critical Care Medicine·Fabienne DecrueUNKNOWN BILD study group
Oct 14, 2021·International Journal of Environmental Health Research·Eda ÜnalGüven Özkaya

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