Prenatal origin of childhood AML occurs less frequently than in childhood ALL.

BMC Cancer
Tatiana BurjanivovaJan Zuna

Abstract

While there is enough convincing evidence in childhood acute lymphoblastic leukemia (ALL), the data on the pre-natal origin in childhood acute myeloid leukemia (AML) are less comprehensive. Our study aimed to screen Guthrie cards (neonatal blood spots) of non-infant childhood AML and ALL patients for the presence of their respective leukemic markers. We analysed Guthrie cards of 12 ALL patients aged 2-6 years using immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements (n = 15) and/or intronic breakpoints of TEL/AML1 fusion gene (n = 3). In AML patients (n = 13, age 1-14 years) PML/RARalpha (n = 4), CBFbeta/MYH11 (n = 3), AML1/ETO (n = 2), MLL/AF6 (n = 1), MLL/AF9 (n = 1) and MLL/AF10 (n = 1) fusion genes and/or internal tandem duplication of FLT3 gene (FLT3/ITD) (n = 2) were used as clonotypic markers. Assay sensitivity determined using serial dilutions of patient DNA into the DNA of a healthy donor allowed us to detect the pre-leukemic clone in Guthrie card providing 1-3 positive cells were present in the neonatal blood spot. In 3 patients with ALL (25%) we reproducibly detected their leukemic markers (Ig/TCR n = 2; TEL/AML1 n = 1) in the Guthrie card. We did not find patient-specific molecular markers in any patie...Continue Reading

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Citations

May 14, 2011·Leukemia·B V BalgobindM M Van den Heuvel-Eibrink
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Susan E PuumalaLogan G Spector
Jan 9, 2010·Environmental Health Perspectives·Michelle C TurnerDaniel Krewski
Apr 27, 2011·Ciência & saúde coletiva·Michelle C TurnerDaniel Krewski
Jul 1, 2010·Genes, Chromosomes & Cancer·Jan ZunaJan Trka
Oct 22, 2008·Genes, Chromosomes & Cancer·Jan ZunaJan Trka
Jan 7, 2020·Cancer Metastasis Reviews·Daniel HeinUte Fischer
May 11, 2021·Frontiers in Pediatrics·Erin L MarcotteHeather H Nelson

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Methods Mentioned

BETA
PCR
PCRs

Software Mentioned

INFORMAX
VECTOR NTI 8 Suite
Chromas
BLAST

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