Prenatal origin of separate evolution of leukemia in identical twins

Leukemia
O TeuffelF K Niggli

Abstract

Several studies involving identical twins with concordant leukemia and retrospective scrutiny of archived neonatal blood spots have shown that the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia (ALL) frequently arises before birth. A prenatal origin of childhood leukemia was further supported by the detection of clonotypic immunoglobulin gene rearrangements on neonatal blood spots of children with various other subtypes of ALL. However, no comprehensive study is available linking these clonotypic events. We describe a pair of 5-year-old monozygotic twins with concordant TEL-AML1-positive ALL. Separate leukemic clones were identified in the diagnostic samples since distinct IGH and IGK-Kde gene rearrangements could be detected. Additional differences characterizing the leukemic clones included an aberration of the second, nonrearranged TEL allele observed in one twin only. Interestingly, both the identical TEL-AML1 fusion sequence and distinct immunoglobulin gene rearrangements were identified on the neonatal blood spots indicating that separate preleukemic clones evolved already before birth. Finally, we compared the reported twins with an additional 31 children with ALL by using the microarray technology. Gene ...Continue Reading

Associated Datasets

References

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Citations

Feb 13, 2008·Omics : a Journal of Integrative Biology·Harmen H M DraismaThomas Hankemeier
Mar 7, 2014·Nature Reviews. Cancer·Glenn M MarshallWilliam A Weiss
Oct 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hatem E SabaawyDennis D Hickstein
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Aug 18, 2010·Blood·Ulrik Lausten-ThomsenKjeld Schmiegelow
Jan 28, 2017·PloS One·Christian KreisUNKNOWN Swiss Paediatric Oncology Group and the Swiss National Cohort Study Group
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Feb 17, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lindsay A WilliamsLogan G Spector

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