Prenatal phthalate exposure and reproductive function in young men

Environmental Research
Jonatan AxelssonAleksander Giwercman

Abstract

Prenatal exposure to phthalates is suggested to negatively impact male reproductive function, but human data are lacking. To study associations between prenatal exposure to diethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP), and reproductive parameters of adolescent men. Using linear regression models adjusted for potential confounders, we studied associations between levels of DEHP- and DiNP metabolites in maternal sera from mean 12 weeks of pregnancy, and testicular size, semen quality and reproductive hormones in 112 adolescent sons, recruited from the general population. Men in the highest exposure tertile of one DiNP metabolite [mono-(carboxy-iso-octyl) phthalate], compared with men in the lowest tertile had: 4.3mL (95% CI: 0.89, 7.6mL; p<0.001) lower total testicular volume; 30% (95% CI: 3.6, 63%; p=0.02) higher levels of follicle-stimulating hormone; and 0.87mL (95% CI: 0.28, 1.5mL; p=0.004) lower semen volume. Men in the highest exposure tertile of one DEHP metabolite [mono-(2-ethyl-5-hydroxylhexyl) phthalate] had 0.70mL (95% CI: 0.090, 1.3mL; p=0.03) lower semen volume than men in the lowest exposure tertile. The levels of two DiNP metabolites [mono-(hydroxy-iso-nonyl) phthalate and mono-(oxo-iso-nonyl) phth...Continue Reading

References

Jan 1, 1990·Epidemiology·K J Rothman
Feb 3, 2000·Human Reproduction·A G AndersenN E Skakkebaek
Dec 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·L E GrayL Parks
Apr 12, 2001·Journal of Clinical Epidemiology·R Bender, S Lange
Jan 25, 2005·Toxicology·Thomas StrohekerMarie-Christine Chagnon
Aug 3, 2005·PLoS Medicine·John P A Ioannidis
Dec 22, 2006·International Journal of Hygiene and Environmental Health·Hermann FrommeBernhard Liebl
Dec 12, 2007·International Journal of Andrology·Matthias Wittassek, Jürgen Angerer
Mar 20, 2008·Fertility and Sterility·Richard M Sharpe, Niels E Skakkebaek
Apr 17, 2008·Environmental Health Perspectives·Jennifer J AdibiRuss Hauser
Jul 22, 2008·Environment International·Po-Chin HuangChing-Chang Lee
Jan 24, 2009·Environmental Health Perspectives·Erin P HinesSuzanne E Fenton
Feb 19, 2009·Journal of Exposure Science & Environmental Epidemiology·Jennifer David PeckSusan L Schantz
Mar 12, 2009·Journal of Exposure Science & Environmental Epidemiology·Donna Day BairdAllen J Wilcox
Mar 13, 2009·Trends in Endocrinology and Metabolism : TEM·Guo-Xin HuXiao-Kun Li
Jul 2, 2009·Environmental Health and Preventive Medicine·Yayoi SuzukiHiroaki Shiraishi
Dec 17, 2009·International Journal of Andrology·D J MacleodS van den Driesche
Jun 22, 2010·Molecular Nutrition & Food Research·Matthias WittassekThomas Brüning
Aug 13, 2010·Chemosphere·Elizabeth Ann IrvinLuke P Naeher
Oct 19, 2010·Journal of Toxicology and Environmental Health. Part a·Tae Sung KimTae Seok Kang
Jun 24, 2011·International Journal of Andrology·Y SuzukiH Shiraishi
Feb 10, 2012·Epidemiology·Cécile ChevrierSylvaine Cordier
Mar 9, 2012·Environmental Health Perspectives·Morten Søndergaard JensenBo A G Jönsson
Mar 10, 2012·Human Reproduction·C Desdoits-LethimonierB Jégou
May 9, 2012·Indoor Air·F CarlstedtC-G Bornehag
Jun 16, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kamin J JohnsonKim Boekelheide
Jul 11, 2013·PloS One·Jonatan AxelssonAleksander Giwercman
Oct 3, 2013·Breast Cancer Research : BCR·Antonia M CalafatMary S Wolff
Nov 29, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Daniel J SpadeKim Boekelheide
Dec 19, 2013·Journal of Developmental Origins of Health and Disease·L P Bustamante-MontesV H Borja-Aburto
Mar 4, 2014·Environment International·Ina Olmer SpechtJens Peter E Bonde
Jun 7, 2014·Critical Reviews in Toxicology·Vanessa R KayWarren G Foster
Nov 11, 2014·Epidemiology·Morten Søndergaard JensenGunnar Toft

❮ Previous
Next ❯

Citations

Jan 5, 2017·Nature Reviews. Urology·Helena E VirtanenJorma Toppari
Jan 17, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Catheryne Chiang, Jodi A Flaws
Jan 31, 2020·The Journal of Clinical Endocrinology and Metabolism·Miriam J WoodwardLeonardo Trasande
Aug 14, 2020·International Journal of Environmental Health Research·Aylin BalcıBelma Kocer-Gumusel
Oct 3, 2020·Critical Reviews in Toxicology·Shalenie P Den Braver-SewradjEllen V S Hessel
Mar 18, 2020·International Journal of Molecular Sciences·Andressa GonsioroskiJodi A Flaws
Aug 9, 2020·Clinical Epidemiology·Katia Keglberg HærvigSandra Søgaard Tøttenborg
May 16, 2019·Environmental Science and Pollution Research International·Yahua LiLi Zhou
Oct 31, 2020·Biology of Reproduction·Shuhong YangRomana A Nowak
Feb 25, 2021·Environmental Science & Technology·Yu WangXin Jiang
Sep 4, 2021·Journal of Exposure Science & Environmental Epidemiology·Anna-Sofia PreeceHuan Shu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.