PMID: 15373950Sep 18, 2004Paper

Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth

The Proceedings of the Nutrition Society
I Caroline McMillenB S Yuen

Abstract

Exposure to either an increased or decreased level of intrauterine nutrition can result in an increase in adiposity and in circulating leptin concentrations in later life. In animals such as the sheep and pig in which fat is deposited before birth, leptin is synthesised in fetal adipose tissue and is present in the fetal circulation throughout late gestation. In the sheep a moderate increase or decrease in the level of maternal nutrition does not alter fetal plasma leptin concentrations, but there is evidence that chronic fetal hyperglycaemia and hyperinsulinaemia increase fetal fat mass and leptin synthesis within fetal fat depots. Importantly, there is a positive relationship between the relative mass of the 'unilocular' component of fetal perirenal and interscapular adipose tissue and circulating fetal leptin concentrations in the sheep. Thus, as in the neonate and adult, circulating leptin concentrations may be a signal of fat mass in fetal life. There is also evidence that leptin can act to regulate the lipid storage, leptin synthetic capacity and potential thermogenic functions of fat before birth. Thus, leptin may act as a signal of energy supply and have a 'lipostatic' role before birth. Future studies are clearly requi...Continue Reading

References

Oct 1, 1978·Australian Journal of Biological Sciences·G Alexander
Oct 1, 1978·Australian Journal of Biological Sciences·R T Gemmell, G Alexander
Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
Jun 1, 1992·Journal of Epidemiology and Community Health·C M LawS J Simmonds
Dec 1, 1991·Diabetes·B L SilvermanB E Metzger
Feb 18, 1995·BMJ : British Medical Journal·C H FallT W Meade
May 1, 1994·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G Dörner, A Plagemann
Dec 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·L A CampfieldP Burn
May 1, 1997·The Journal of Clinical Endocrinology and Metabolism·C SchubringW F Blum
Dec 31, 1997·BMJ : British Medical Journal·H T SørensenT I Sørensen
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·N HoggardJ G Mercer
Apr 29, 1998·The Journal of Clinical Endocrinology and Metabolism·D JaquetP Czernichow
Jun 20, 1998·Science·S C WoodsM W Schwartz
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Apr 30, 1999·Physiological Reviews·E Jéquier, L Tappy
Jun 18, 1999·The Journal of Clinical Endocrinology and Metabolism·T A Buchanan, S L Kjos
Sep 16, 1999·American Journal of Obstetrics and Gynecology·J LepercqS H Mouzon
Nov 11, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D I PhillipsP C Owens
Dec 10, 1999·The Journal of Endocrinology·B S YuenP C Owens
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Jun 1, 2000·The Journal of Endocrinology·D BlacheG B Martin
Jun 9, 2000·Annual Review of Physiology·R S Ahima, J S Flier
Jun 10, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·S Manzar
Oct 24, 2000·Obstetrics and Gynecology·A WiznitzerM Mazor
Dec 12, 2001·Molecular and Cellular Endocrinology·B H BreierW P Wong
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard A EhrhardtYves R Boisclair
Jun 6, 2002·The Journal of Dairy Research·Aurore Rincheval-ArnoldJean Djiane
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B S J YuenI C McMillen

❮ Previous
Next ❯

Citations

Jan 12, 2012·Archives of Gynecology and Obstetrics·Eileen R FowlesGayle M Timmerman
May 27, 2010·Nutrition Research Reviews·Paul GuilloteauCornelia C Metges
Apr 1, 2008·Animal : an International Journal of Animal Bioscience·M P TygesenM O Nielsen
Dec 7, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G MoschonisY Manios
Dec 14, 2005·Prostate Cancer and Prostatic Diseases·R RibeiroR Medeiros
Aug 16, 2012·The Journal of Medicine and Philosophy·Jason Morris
Aug 30, 2011·Nursing Research·Eileen R FowlesAdama Brown
Jan 17, 2009·The Journal of Clinical Investigation·Carrie E McCurdyKevin L Grove
Sep 18, 2008·PloS One·Cristianne R M FrazierJeff A Beeler
Jan 11, 2007·Clinical Medicine & Research·Delia-Marina AlexeEleni Th Petridou
May 4, 2011·World Journal of Diabetes·Zhong-Cheng LuoAnne-Monique Nuyt
Sep 30, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·S P SébertM E Symonds
Dec 18, 2013·The British Journal of Nutrition·Amanda Brondani MucelliniGilberto Luiz Sanvitto
Jan 25, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·D S GardnerM E Symonds
Dec 20, 2008·European Journal of Endocrinology·Despina D Briana, Ariadne Malamitsi-Puchner
Feb 19, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·M D Saenz-de-JuanoJ S Vicente
Nov 23, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Donald A NovakMichael G Ross
Nov 5, 2013·The Veterinary Clinics of North America. Food Animal Practice·Richard N Funston, Adam F Summers
Sep 21, 2010·Archives of Medical Research·Consuelo Treviño-GarzaJesús Argente
Aug 12, 2009·Economics and Human Biology·Anne Case, Alicia Menendez
May 17, 2008·Seminars in Perinatology·Michael G Ross, Marie H Beall
Mar 5, 2016·Hormone Molecular Biology and Clinical Investigation·Erin M Rhinehart
Aug 11, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sorina Grisaru-GranovskyDeborah Elstein
May 14, 2016·Metabolism: Clinical and Experimental·Polyxeni KarakostaLeda Chatzi
Feb 12, 2005·The Journal of Physiology·I Caroline McMillenBeverly S Mühlhäusler
Dec 17, 2008·Annals of the New York Academy of Sciences·Claire-Dominique WalkerBouziane Azeddine
Oct 29, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Claire-Dominique Walker
Feb 15, 2011·Journal of Obesity·Joselyn RojasValmore Bermúdez
Feb 6, 2014·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Francisco Marco-JiménezJose S Vicente
Jan 1, 2006·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Iosif Kelesidis, Christos S Mantzoros
Dec 7, 2007·American Journal of Obstetrics and Gynecology·Regina TrollmannJörg Dötsch
May 6, 2008·American Journal of Obstetrics and Gynecology·Emanuela MarinoniRomolo Di Iorio
Mar 19, 2014·Physiology & Behavior·Silvana JacobsGilberto L Sanvitto
Apr 29, 2015·PloS One·Maria Desemparats Saenz-de-JuanoFrancisco Marco-Jiménez
Jan 1, 2013·Annual Review of Animal Biosciences·R N Funston, A F Summers
Dec 31, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Hiraku Nagasaki, Takao Ohta
Dec 7, 2010·Western Journal of Nursing Research·Eileen R FowlesSunghun Kim
Jun 3, 2017·Diabetes·Kristin I StanfordLaurie J Goodyear

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.