Prenatal protein malnutrition decreases mossy fibers-CA3 thorny excrescences asymmetrical synapses in adult rats

Brain Research
Leticia Granados-RojasSofía Díaz-Cintra

Abstract

Prenatal protein malnutrition has deleterious effects on hippocampal structure and function that likely result from decreased synapse number. We thus evaluated long-term effects of prenatal protein malnutrition on the mossy fibers-CA3 thorny excrescences asymmetrical synapses in 220-day-old rats. Protein malnourished rats born from pregnant dams fed with 6% casein diet were cross-fostered to lactating control rats at birth. Control animals were fed with a 25% casein diet. Timm's stained material was used to estimate the total reference volume of the mossy fiber system suprapyramidal bundle by means of stereology. The mossy fiber-CA3 asymmetrical synapse numerical density was obtained by electron microscopy, using the physical disector method. The total number of mossy fiber-CA3 asymmetrical synapses was determined on the basis of the total reference volume of the mossy fiber system suprapyramidal bundle and the mossy fiber-CA3 asymmetrical synapse numerical density. Prenatal protein malnutrition produced long-lasting, significant decreases in the volume of the mossy fiber system suprapyramidal bundle and in the numerical density of mossy fiber-CA3 asymmetrical synapse, suggesting a reduction in the total number of this synapse ...Continue Reading

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Citations

Feb 9, 2006·Journal of Neural Transmission·M Lauer, D Senitz
Apr 11, 2012·Neuroscience and Biobehavioral Reviews·Meryem Alamy, Wail A Bengelloun
Apr 13, 2005·Brain Research·Fernanda BonattoJosé Cláudio Fonseca Moreira
Mar 3, 2015·Nutritional Neuroscience·Susana Angelica Castro-ChaviraSofia Diaz-Cintra
Sep 22, 2017·Frontiers in Neuroanatomy·Alfredo Varela-EchevarríaJorge Larriva-Sahd
Jul 31, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·E Padilla-GómezS Diaz-Cintra
Jun 3, 2021·Children·Rachael M TaylorClare E Collins

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