Prenatal screening for thrombophilias: indications and controversies

Clinics in Laboratory Medicine
Jeanine F Carbone, Roxane Rampersad

Abstract

A thrombophilia is defined as a disorder of hemostasis that predisposes a person to a thrombotic event. Data suggest that at least 50% of cases of venous thromboembolism in pregnant women are associated with an inherited or acquired thrombophilia, which can lead to an increased risk of maternal thromboembolism and adverse pregnancy outcomes such as recurrent pregnancy loss, intrauterine fetal demise, preterm preeclampsia, and intrauterine growth restriction. Inherited and acquired thrombophilias have different indications for testing. This article examines screening procedures for thrombophilias in the setting of adverse pregnancy outcomes.

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Citations

Jun 10, 2016·The Annals of Pharmacotherapy·Kenneth A BauerJeffrey B Spears
May 26, 2017·The Journal of Obstetrics and Gynaecology Research·Evgeny ReshetnikovMikhail Churnosov

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