Prenatal Selective Serotonin Reuptake Inhibitor Use and Associated Risk for Gestational Hypertension and Preeclampsia: A Meta-Analysis of Cohort Studies

Journal of Women's Health
Hong-Bo GuanCai-Xia Liu

Abstract

To analyze existing cohort studies and provide evidence for the use of prenatal selective serotonin reuptake inhibitor (SSRI) monotherapy and the associated risk of gestational hypertension and preeclampsia. A comprehensive search of English language articles published before 30th April 2017 was conducted on PubMed, EMBASE, and the Web of Science databases. Using data acquired, we summarized the relative risks (RRs) and 95% confidence intervals (CIs) of gestational hypertension and preeclampsia using the random-effects model. Heterogeneity between studies was also assessed with the I2 statistic. Seven cohort studies with 1,108,261 individuals were included for analysis. Compared with nonusers, those undertaking prenatal SSRI monotherapy were more likely to develop gestational hypertension or preeclampsia (summarized RR = 1.21, 95% CI: 1.05-1.40, I2 = 71.3%), gestational hypertension (summarized RR = 1.14, 95% CI: 1.00-1.30, I2 = 5.7%), and preeclampsia (summarized RR = 1.32, 95% CI: 0.99-1.78, I2 = 83.3%). In addition, although subgroup analyses, which were stratified by study design, number of cases, geographic location, duration of SSRI monotherapy, registry databases, and adjustment for potential confounders and risk factors...Continue Reading

References

Jan 1, 1990·Gynecologic and Obstetric Investigation·C GonzalezM I Rudolph
Aug 1, 1990·American Journal of Obstetrics and Gynecology·A F SaftlasR Pokras
Apr 1, 1989·Journal of Consulting and Clinical Psychology·I H GotlibN I Cordy
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·K Bjøro, S Stray-Pedersen
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Aug 1, 1994·American Journal of Epidemiology·S Greenland
Jul 1, 1998·British Journal of Obstetrics and Gynaecology·I T ManyondaC Wilson
Sep 7, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·R J KaajaM G Nicholls
Sep 24, 1999·JAMA : the Journal of the American Medical Association·P JüniM Egger
Oct 16, 1999·American Journal of Obstetrics and Gynecology·A Conde-AgudeloA C Kafury-Goeta
Mar 22, 2000·Obstetrics and Gynecology·T KurkiO Ylikorkala
Mar 27, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A C BolteG A Dekker
Aug 4, 2001·BMJ : British Medical Journal·J EvansJ Golding
Feb 1, 2002·American Journal of Epidemiology·Xu XiongWilliam D Fraser
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jul 21, 2005·Annals of Epidemiology·Lisa M BodnarJames M Roberts
Sep 24, 2005·Obstetrics and Gynecology·UNKNOWN ACOG Committee on Practice Bulletins--Obstetrics
Jul 25, 2006·Acta Obstetricia Et Gynecologica Scandinavica·Berit L DahlstrømPål Oian
Jun 6, 2007·American Journal of Obstetrics and Gynecology·William O CooperWayne A Ray
Oct 2, 2007·American Journal of Obstetrics and Gynecology·Susan E AndradeRichard Platt
Apr 26, 2008·American Journal of Hypertension·Anne B WallisHani K Atrash
Jan 6, 2009·The American Journal of Psychiatry·Sengwee TohSonia Hernández-Díaz
Feb 7, 2009·American Journal of Hypertension·Chunfang QiuTanya K Sorensen
Jun 23, 2009·BMJ : British Medical Journal·Sonia Hernández-DíazSven Cnattingius
Mar 23, 2012·British Journal of Clinical Pharmacology·Mary A De Vera, Anick Bérard
Mar 24, 2012·American Journal of Epidemiology·Kristin PalmstenSonia Hernández-Díaz
Nov 24, 2012·International Journal of Cancer. Journal International Du Cancer·Ting-Ting GongYong-Lai Wang
Jul 23, 2013·Epidemiology·Kristin PalmstenSonia Hernández-Díaz
Aug 24, 2013·The American Journal of Clinical Nutrition·Nan-Nan LuanBei Lin
Oct 30, 2013·Nutrition Reviews·Arun Jeyabalan
Mar 18, 2015·CNS Spectrums·Lyndsay Ammon AvalosDe-Kun Li
Jun 16, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Qi-Jun WuTing-Ting Gong
Oct 19, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·A C EkeV Berghella

❮ Previous
Next ❯

Citations

Oct 3, 2019·JAMA Psychiatry·Elena DragiotiEvangelos Evangelou
Aug 23, 2020·International Journal of Molecular Sciences·Sabrina I HanswijkJudith R Homberg

❮ Previous
Next ❯

Software Mentioned

Stata12

Related Concepts