Prenatal social stress in the rat programmes neuroendocrine and behavioural responses to stress in the adult offspring: sex-specific effects

Journal of Neuroendocrinology
P Brunton, John A Russell

Abstract

Stress exposure during pregnancy can 'programme' adult behaviour and hypothalamic-pituitary-adrenal (HPA) axis stress responsiveness. In the present study, we utilised an ethologically relevant social stressor to model the type of stress that pregnant women may experience. We investigated the effects of social defeat by a resident lactating rat over 5 days during the last week of pregnancy on the pregnant intruder rat HPA axis, and on HPA responsivity to stress and anxiety-related behaviour in the adult offspring of the socially-defeated intruder rats. HPA axis responses after social defeat were attenuated in the pregnant rats compared to virgin females. In the adult offspring, systemic interleukin (IL)-1beta or restraint increased adrenocorticotrophic hormone and corticosterone secretion in male and female control rats; however, in prenatally stressed (PNS) offspring, HPA responses were greatly enhanced and peak hormone responses to IL-1beta were greater in females versus males. Male PNS rats displayed increased anxiety behaviour on the elevated plus maze; however, despite marked changes in anxiety behaviour across the oestrous cycle, there were no differences between female control and PNS rats. Investigation of possible mech...Continue Reading

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Citations

Oct 16, 2010·Psychopharmacology·Julie A Markham, James I Koenig
Sep 28, 2010·Brain Research·Paula J Brunton, John A Russell
Nov 12, 2013·Neuropeptides·Benjamin Nephew, Chris Murgatroyd
May 15, 2012·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A Fernández-GuastiR J Handa
Feb 23, 2013·The Journal of Endocrinology·Paula J BruntonAmanda J Drake
Jan 11, 2011·Interdisciplinary Toxicology·Michal Dubovický
Jun 26, 2013·Journal of Visualized Experiments : JoVE·Lindsay M CariniBenjamin C Nephew
Sep 10, 2013·Progress in Neurobiology·Paula J BruntonJonathan J Hirst
Aug 1, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Paula J Brunton
May 28, 2014·Nature Reviews. Endocrinology·Vasilis G Moisiadis, Stephen G Matthews
Dec 7, 2014·The Journal of Endocrinology·Takahiro NemotoTamotsu Shibasaki
Jul 3, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Irene Esteban-CornejoUNKNOWN UP & DOWN Study Group
Jun 15, 2011·Stress : the International Journal on the Biology of Stress·Tracy L Bale
Jul 28, 2011·Stress : the International Journal on the Biology of Stress·M Weinstock
Dec 22, 2010·The Journal of Physiology·Amita Kapoor, Stephen G Matthews
May 21, 2010·Hormones and Behavior·Gregory A DunnTracy L Bale
Aug 25, 2015·Behavioural Brain Research·Luciana Taschetto VeyMarilise Escobar Burger
Jan 19, 2012·Developmental Psychobiology·Mariana SchroederAron Weller
Jul 25, 2012·American Journal of Physical Anthropology·Kelsey Needham DancauseSuzanne King
Nov 27, 2010·Journal of Neuroendocrinology·S SalomonM Weinstock
Jul 22, 2014·Journal of Neuroendocrinology·S MaccariP J Brunton
Apr 16, 2015·Journal of Integrative Neuroscience·N SaidA Tazi
Jul 15, 2015·Journal of Developmental Origins of Health and Disease·H M SickmannM P Kristensen
Aug 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefanie L Bronson, Tracy L Bale
Aug 12, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Paula J Brunton
Jan 11, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Paula J Brunton, John A Russell
Jun 29, 2012·Stress : the International Journal on the Biology of Stress·L PaternainJ Campión
Apr 30, 2015·Nature Reviews. Neuroscience·Tracy L Bale

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