Prenatal sonographic diagnosis of congenital heart disease and intrauterine growth restriction: a case-control study

Journal of Clinical Ultrasound : JCU
Annette Perez-Delboy, Lynn L Simpson

Abstract

To determine the prevalence of intrauterine growth restriction (IUGR) in cases of congenital heart disease (CHD) and to evaluate whether the prenatal diagnosis of isolated CHD was a significant risk factor for IUGR. We conducted a retrospective case-control study of prenatally detected CHD with delivery at >/=20 weeks' gestation between January 1, 1998, and December 31, 2001. Four groups were analyzed: (1) all cases with CHD, (2) after exclusion of abnormal karyotype, (3) after exclusion of abnormal karyotype and prenatally diagnosed extracardiac anomaly, and (4) after exclusion of abnormal karyotype and prenatally and postnatally diagnosed extracardiac anomaly. The prevalence of IUGR was determined in each of the 4 study groups and was compared with controls. There were 13,395 deliveries at >/=20 weeks' gestation. Of the 180 cases of CHD, 22.8% were associated with IUGR compared with 11.6% of controls (p < 0.01). In contrast, there was no statistically significant difference in the prevalence of IUGR in the 140 cases of isolated CHD compared with controls (12.9% versus 10.0%). The prenatal detection of isolated CHD does not seem to be associated with IUGR.

References

Oct 1, 1991·American Journal of Obstetrics and Gynecology·G M JacksonA W Cohen
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Jan 1, 1982·Cytogenetics and Cell Genetics·E B Hook
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Mar 30, 2001·The Journal of Thoracic and Cardiovascular Surgery·P M VerheijenG B Bennink
Jan 31, 2002·Clinics in Perinatology·Lynn L Simpson

Citations

Aug 19, 2011·Fetal Diagnosis and Therapy·Mina ItsukaichiKenichi Tanaka
Aug 10, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Matthew B WallensteinAlison G Cahill
Oct 16, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·April D AdamsSara N Iqbal

Related Concepts

Fetal Growth Retardation
Congenital Heart Defects
Retrospective Studies
Comorbidity
Nested Case-Control Studies
Fetal Ultrasonography

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

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