Prenatal steroids for microcystic congenital cystic adenomatoid malformations

Journal of Pediatric Surgery
Patrick F CurranHanmin Lee

Abstract

The purpose of this study is to evaluate the effect of prenatal steroid treatment in fetuses with sonographically diagnosed congenital cystic adenomatoid malformations (CCAMs). This was an institutional review board-approved retrospective review of 372 patients referred to the University of California, San Francisco (UCSF), for fetal CCAM. Inclusion criteria were (1) a predominately microcystic CCAM lesion sonographically diagnosed at our institution, (2) maternal administration of a single course of prenatal corticosteroids (betamethasone), and (3) no fetal surgery. CCAM volume-to-head ratio (CVR), presence of hydrops, mediastinal shift, and diaphragm eversion were assessed before and after administration of betamethasone. The primary end points were survival to birth and neonatal discharge. Sixteen patients with predominantly microcystic CCAMs were treated with prenatal steroids. Three were excluded because of lack of follow-up information. All remaining fetuses (13/13) survived to delivery and 11/13 (84.6%) survived to neonatal discharge. At the time of steroid administration, all patients had CVR greater than 1.6, and 9 (69.2%) also had nonimmune hydrops fetalis. After a course of steroids, CVR decreased in 8 (61.5%) of the...Continue Reading

References

Oct 1, 1985·Journal of Pediatric Surgery·N S AdzickR A Filly
Oct 1, 1993·Journal of Pediatric Surgery·T E MacGillivrayN S Adzick
Oct 28, 1998·American Journal of Obstetrics and Gynecology·N S AdzickL J Howell
Oct 10, 2003·Clinics in Perinatology·N Scott Adzick
Jan 9, 2007·Journal of Pediatric Surgery·Erich J GrethelHanmin Lee
Feb 3, 2007·Journal of Pediatric Surgery·Shaun M KunisakiRussell W Jennings
Oct 29, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·P CavorettoK H Nicolaides
Jan 23, 2009·Journal of Pediatric Surgery·Lee M MorrisTimothy M Crombleholme

❮ Previous
Next ❯

Citations

Jan 21, 2012·Pediatric Radiology·Leonor AlamoReto Meuli
Dec 5, 2013·Journal of Molecular Endocrinology·Eva A Rog-ZielinskaKaren E Chapman
Dec 3, 2014·Seminars in Pediatric Surgery·Robert BairdJean-Martin Laberge
Nov 27, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Anna G EuserTimothy M Crombleholme
Feb 12, 2013·Seminars in Pediatric Surgery·Nahla Khalek, Mark P Johnson
Jan 22, 2013·Journal of Pediatric Surgery·Darrell L CassTimothy C Lee
Aug 19, 2015·Prenatal Diagnosis·Maisa FeghaliStephen P Emery
Nov 21, 2012·Clinics in Perinatology·Christopher E ColbySusan R Hintz
Aug 4, 2012·The Annals of Thoracic Surgery·Offir Ben-IshayTerry L Buchmiller
Jun 12, 2012·Clinics in Perinatology·Pramod S Puligandla, Jean-Martin Laberge
Jun 12, 2012·Best Practice & Research. Clinical Obstetrics & Gynaecology·Tim van MieghemJan Deprest
Mar 20, 2012·Seminars in Fetal & Neonatal Medicine·Timothy C Lee, Oluyinka O Olutoye
Jan 17, 2012·Journal of Pediatric Surgery·Darrell L CassM Regina L Lantin
Jul 30, 2011·Early Human Development·Ruben S WitloxFrans J Walther
Jun 21, 2011·Journal of Pediatric Surgery·David A LazarOluyinka O Olutoye
Feb 5, 2011·Journal of Pediatric Surgery·Darrell L CassBella Belleza-Bascon
Nov 9, 2010·Advances in Pediatrics·Miho Watanabe, Alan W Flake
Jan 1, 2012·Scientifica·Montasser NadeemPeter Greally
May 29, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D BaudG Ryan
Jun 4, 2011·Prenatal Diagnosis·Lisa Hui, Diana W Bianchi
Jan 10, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S SchreyG Ryan
May 28, 2011·Prenatal Diagnosis·Ruben S WitloxDick Oepkes
Mar 5, 2015·Prenatal Diagnosis·Jérôme MathisDavid Baud
Jun 9, 2015·Seminars in Pediatric Surgery·Katarzyna Gajewska-Knapik, Lawrence Impey
Nov 20, 2012·American Journal of Obstetrics and Gynecology·Stacey Ehrenberg-BuchnerShaun M Kunisaki
Jan 6, 2015·Pediatric Surgery International·Muhammad Choudhry, David Drake
Jul 25, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Tara A Morgan, Vickie A Feldstein
Mar 20, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Cécile GuenotYvan Vial
Jun 11, 2017·Journal of Perinatal Medicine·Ahmed A NassrAlireza A Shamshirsaz
Aug 8, 2014·Obstetrical & Gynecological Survey·Paolo SalaPierangela De Biasio
Oct 1, 2019·Journal of Clinical Ultrasound : JCU·Anastasiya HolubyevaSteven Bush
Dec 14, 2017·Annual Review of Animal Biosciences·Sandra K KabagambeDiana L Farmer
Jan 12, 2020·Prenatal Diagnosis·Teresa VictoriaN Scott Adzick
Jun 30, 2019·Frontiers in Pediatrics·Federica AnnunziataFrancesca Santamaria
Jan 7, 2017·Pediatric Surgery International·H Kitagawa, K C Pringle
Aug 14, 2020·Seminars in Immunopathology·Ignacio ValenzuelaLiesbeth Lewi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.