PMID: 9544707Apr 17, 1998

Prenatal strategies for reducing severe thalassemia in pregnancy

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Chanane WanapirakA Tuggapichitti

Abstract

To describe the prenatal strategy in reducing new cases of severe thalassemia at Maharaj Nakorn Chiang Mai Hospital. The study design involved a prospective descriptive analysis set in Maharaj Nakorn Chiang Mai Hospital, Chiang Mai University. Pregnant women attending antenatal clinic. The strategy included: (1) carrier identification by retrospective (history review) and prospective screening program; (2) the couples at risk were counseled and offered cordocentesis; (3) analysis of fetal blood with high performance liquid chromatography (HPLC) or electrophoresis; and (4) counseling for termination of pregnancy in case of affected fetus. The prospective screening consisted of testing for a carrier by a simple erythrocyte osmotic fragility test (EOFT) in women with no risk and testing the husbands of the women with abnormal tests. A pregnancy in which both of the couple were carriers was considered a risk. Cordocentesis was performed in 554 pregnancies at risk, 252 and 302 from retrospective and prospective screening, respectively. Sixty of 252 of the first group had severe thalassemia. In the prospective screening program of 12 680 women, 459 risk couples were identified, 302 pregnancies underwent cordocentesis and 53 (17.5%) h...Continue Reading

Citations

May 15, 2009·International Journal of Hematology·Chatchai TayapiwatanaWatchara Kasinrerk
Feb 26, 2010·BMC Blood Disorders·Montarat ThavorncharoensapBang-On Ubol
Jul 14, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Supatra SirichotiyakulTheera Tongsong
Apr 5, 2013·Prenatal Diagnosis·Theera TongsongSavitree Pranpanus
May 27, 2005·The Journal of Obstetrics and Gynaecology Research·Supatra SirichotiyakulTheera Tongsong
Jan 24, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Xinyan LiYili Zhao
Aug 25, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Supatra SirichotiyakulTheera Tongsong
Jul 11, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Theera TongsongChanane Wanapirak
Dec 11, 1999·Prenatal Diagnosis·Theera TongsongSupatra Sirichotiyakul
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Dec 2, 2014·Obstetrics and Gynecology·Theera TongsongKuntharee Trisrisilp
Dec 2, 2000·Bone Marrow Transplantation·M A GertzM R Litzow
Aug 21, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Keooudone ThammavongTheera Tongsong
Feb 6, 2004·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Theera TongsongPharuhas Chanprapaph

Related Concepts

Carrier of Disorder
Embryopathies
Antenatal Screening Procedures
Alpha-Thalassemia
Thalassemia Minor
Intrauterine Cordocentesis

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