Prenatal stress programs neuroendocrine stress responses and affective behaviors in second generation rats in a sex-dependent manner

Psychoneuroendocrinology
Natalia J Grundwald, Paula J Brunton

Abstract

An adverse environment in early life is often associated with dysregulation of the hypothalamo-pituitary-adrenal (HPA) axis and higher rates of mood disorders in adulthood. In rats, exposure to social stress during pregnancy results in hyperactive HPA axis responses to stress in the adult offspring and heightened anxiety behavior in the males, but not the females. Here we tested whether, without further intervention, the effects of prenatal stress (PNS) in the first filial generation (F1) are transmitted to the F2 generation via the maternal line. F1 control and PNS female rats were mated with control males and housed under non-stress conditions throughout pregnancy. HPA axis responses to acute stress, anxiety- and depressive-like behavior were assessed in the adult F2 offspring. ACTH and corticosterone responses to an acute stressor were markedly enhanced in F2 PNS females compared with controls. This was associated with greater corticotropin releasing hormone (Crh) mRNA expression in the paraventricular nucleus and reduced hippocampal glucocorticoid (Gr) and mineralocorticoid receptor (Mr) mRNA expression. Conversely, in the F2 PNS males, HPA axis responses to acute stress were attenuated and hippocampal Gr mRNA expression wa...Continue Reading

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Citations

Oct 26, 2016·Neurotoxicity Research·Verónica PastorMaría Eugenia Pallarés
Nov 3, 2016·Pediatric Research·Dustin ScheinostLaura R Ment
Mar 14, 2017·Stress : the International Journal on the Biology of Stress·Elnaz NakhjiriDavod Khalafkhani
Dec 26, 2018·Journal of Neuroendocrinology·Hirotaka Hamada, Stephen G Matthews
Nov 15, 2017·Endocrinology·Patrick O McGowan, Stephen G Matthews
Mar 28, 2019·The Journal of Endocrinology·Stephen G Matthews, Patrick O McGowan
Jan 8, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Carolina LuftMárcio Vinícius Fagundes Donadio
May 28, 2019·Stress : the International Journal on the Biology of Stress·Negar AziziLeila Chodari
Apr 24, 2019·The Journal of Endocrinology·E J AgnewK E Chapman
Jan 8, 2021·Frontiers in Behavioral Neuroscience·Kimberly MathesonHymie Anisman
Jan 23, 2021·Neuroscience Letters·Carolina LuftMárcio Vinícius Fagundes Donadio
Feb 26, 2019·Frontiers in Neuroendocrinology·John A Russell, Paula J Brunton
Jul 20, 2021·Behavioural Brain Research·Gabriel Guillén-RuizJuan Francisco Rodríguez-Landa
Aug 20, 2021·Molecular Neurobiology·María Eugenia PallarésMarta Cristina Antonelli

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Methods Mentioned

BETA
antisense oligonucleotides

Software Mentioned

Ethovision XT
Sigmaplot
Image J

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