Prenatal transplantation of human amniotic fluid stem cells for spinal muscular atrophy

Current Opinion in Obstetrics & Gynecology
Shao-Yu Peng, Sheng-Wen S Shaw

Abstract

To review the current medical and stem-cell therapy for spinal muscular atrophy (SMA) and prenatal transplantation of amniotic fluid stem cells in the future. SMA is an autosomal recessive inheritance of neurodegenerative disease, which is caused of the mutation in survival motor neuron. The severe-type SMA patients usually die from the respiratory failure within 2 years after birth. Recently, researchers had found that 3-methyladenine could inhibit the autophagy and had the capacity to reduce death of the neurons. The first food and drug administration-approved drug to treat SMA, Nusinersen, is a modified antisense oligonucleotide to target intronic splicing silencer N1 just recently launched. Not only medical therapy, but also stem cells including neural stem cells, embryonic stem cells, mesenchymal stem cells, and induced pluripotent stem cells could show the potential to repair the injured tissue and differentiate into neuron cells to rescue the SMA animal models. Human amniotic fluid stem cells (HAFSCs) share the potential of mesenchymal stem cells and could differentiate into tri-lineage-relative cells, which are also having the ability to restore the injured neuro-muscular function. In this review, we further demonstrate...Continue Reading

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Citations

Apr 29, 2020·Biotechnology Letters·Hamid Ahmadian-MoghadamMohammad-Reza Zarrindast
Sep 25, 2021·Clinical Obstetrics and Gynecology·Caitlin Baptiste, Darryl C De Vivo

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