Prenatal vanadium exposure, cytokine expression, and fetal growth: A gender-specific analysis in Shanghai MCPC study

The Science of the Total Environment
Yuhan ZhouYunhui Zhang

Abstract

Increasing evidence supports that maternal exposure to vanadium (V) is associated with adverse birth outcomes including preterm birth and low birth weight. However, the effect of V exposure on intrauterine fetal growth and the underlying biological mechanism are still unclear. The present study includes 227 mother-infant pairs from the Shanghai Maternal-Child Pairs Cohort to assess the gender-specific effect of intrauterine V exposure on fetal growth and related cytokines. Maternal blood samples were collected to measure V concentration and biomarkers of growth. We used multiple linear regression to evaluate the gender-specific effect of prenatal V exposure on birth parameter and growth-related cytokines. Mixed-effect models were applied to assess the non-linear association between gestational V exposure and intrauterine fetal growth. Covariates adjusted in the regression models as potential confounders including maternal age, pre-pregnancy body mass index, gestational weeks, parity, socio-demographic status, etc. Results showed that prenatal V exposure was negatively associated with birth weight (β = -64.73) in female newborns and body length (β = -0.10) in male. During the fetal period, maternal V exposure was associated with...Continue Reading

Citations

May 26, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Wenxin ZhangYuanyuan Li
May 18, 2020·Ecotoxicology and Environmental Safety·Pengpeng WangYunhui Zhang

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