Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model

Diabetologia
Bo NiklassonWilliam Klitz

Abstract

It has been suggested that the uterine environment may influence metabolic disease occurring later in adult life, and that adult stress may promote disease outcome. Using a mouse model, we tested whether in utero exposure to Ljungan virus (LV) followed by adult exposure to stress produces diabetes. The influence of the timing of viral exposure over the course of pregnancy was also tested. Pregnant CD-1 mice were exposed i.p. to LV on pregnancy days 4, 8, 12 or 17. Adult male mice from these pregnancies were stressed by being kept in shared cages. Stress only, LV exposure in utero only, and no-stress/no virus exposure groups were also followed. Outcome variables included bodyweight, epididymal fat weight, baseline glucose, glucose tolerance tests (60 and 120 min) and serum insulin. We demonstrated that male mice developed a type 2-like diabetes, including obesity, as adults if infected during pregnancy with LV. Diabetes at the age of 11 weeks was more severe in mice whose mothers were infected earlier than in those whose mothers were infected later in pregnancy. Only animals infected in utero and kept under stress developed diabetes; infection or stress alone did not cause disease. This work demonstrates that a type 2 diabetes-l...Continue Reading

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Citations

Apr 5, 2007·Diabetologia·Bo NiklassonWilliam Klitz
May 2, 2009·Forensic Science, Medicine, and Pathology·Bo NiklassonWilliam Klitz
Aug 22, 2007·Neuroimmunomodulation·Anneli Sepa, Johnny Ludvigsson
Apr 24, 2007·Environmental Health Perspectives·Arthur L PennLarry Lomax
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Oct 14, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Annika SamsioeWilliam Klitz
Jan 8, 2013·General and Comparative Endocrinology·Aleksandra BartelikAlicja Józkowicz
Nov 28, 2013·Medical Hypotheses·K Fukuda
Aug 10, 2016·Viral Immunology·Bo NiklassonWilliam Klitz
Jul 18, 2018·Pediatric Diabetes·Åshild Olsen Faresjö, Johnny Ludvigsson
Mar 6, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bo NiklassonWilliam Klitz
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Jul 9, 2011·Journal of Medical Virology·Bo Niklasson
Aug 1, 2020·Frontiers in Immunology·Ricardo Wesley AlbercaMaria Notomi Sato

Related Concepts

Metazoa
Blood Glucose
Diabetes Mellitus
Diabetes Mellitus, Non-Insulin-Dependent
Insulin B Chain
Obesity
Picornaviridae Infections
Pregnancy Complications, Infectious
Metabolic Stress Response
Impaired Glucose Tolerance