Prenatally versus postnatally diagnosed congenital diaphragmatic hernia - Side, stage, and outcome

Journal of Pediatric Surgery
Carmen Mesas BurgosCongenital Diaphragmatic Hernia Study Group

Abstract

To compare outcomes between prenatally and postnatally diagnosed CDH in a large multicenter database of prospectively collected data and evaluate factors associated with poorer outcome for prenatally diagnosed CDH. We used information from the multicenter, multinational CDH Study Group database on patients born between 2007 and 2015. We compared differences between prenatally and postnatally diagnosed CDH with respect to survival, side, size, ECMO needs, associated major cardiac malformations and liver position. 3746 cases of CDH were entered in the registry between 2007 and 2015, with an overall survival of 71%. Of those, 68% had a prenatal diagnosis. Survival rates were significantly better in the postnatally diagnosed group, 83 vs 65%. There was a higher proportion of bigger defect sizes, C and D, in the prenatally diagnosed group, but the survival rates were similar when patients were stratified by defect size. The rate of ECMO utilization was higher overall in the prenatally diagnosed group, 33 vs 22%, but it was similar within similar defect sizes. Right-sided defects are more commonly missed at prenatal screening than left-sided CDH, 53 vs 35% (p < 0.0001). Prenatally diagnosed CDH is associated with larger defect sizes ...Continue Reading

Citations

May 16, 2019·Pediatric Research·Richard WagnerRichard Keijzer
Oct 2, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J Deprest
Feb 20, 2020·Current Opinion in Obstetrics & Gynecology·Yair J Blumenfeld, Michael A Belfort
Nov 16, 2019·The European Respiratory Journal·Richard WagnerRichard Keijzer
Jun 12, 2020·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Wajid JawaidPaul D Losty
Sep 4, 2021·Ultrasound Quarterly·Eve WigginsTheodore J Dubinsky
Mar 17, 2021·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R A DidierB G Coleman
Mar 26, 2021·Pediatrics·Shaun M KunisakiUNKNOWN MIDWEST PEDIATRIC SURGERY CONSORTIUM
Dec 16, 2021·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Charlotte BendixenWendy Kay Chung

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