Prentice award lecture 2011: removing the brakes on plasticity in the amblyopic brain.

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Dennis M Levi

Abstract

Experience-dependent plasticity is closely linked with the development of sensory function. Beyond this sensitive period, developmental plasticity is actively limited; however, new studies provide growing evidence for plasticity in the adult visual system. The amblyopic visual system is an excellent model for examining the "brakes" that limit recovery of function beyond the critical period. While amblyopia can often be reversed when treated early, conventional treatment is generally not undertaken in older children and adults. However, new clinical and experimental studies in both animals and humans provide evidence for neural plasticity beyond the critical period. The results suggest that perceptual learning and video game play may be effective in improving a range of visual performance measures and importantly the improvements may transfer to better visual acuity and stereopsis. These findings, along with the results of new clinical trials, suggest that it might be time to reconsider our notions about neural plasticity in amblyopia.

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Citations

Jul 25, 2013·Visual Neuroscience·Dennis M Levi
Mar 23, 2013·Psychonomic Bulletin & Review·Kasey L PowersLouis Alfieri
Jul 26, 2014·Eye·S L LiE E Birch
Jun 3, 2014·Vision Research·Mitsuo KawatoTakeo Watanabe
Feb 1, 2015·Vision Research·Dennis M LeviDaphne Bavelier
Apr 29, 2015·Vision Research·Indu VedamurthyDennis M Levi
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Nov 5, 2014·Frontiers in Psychology·Tina PlankMark W Greenlee
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Dec 14, 2017·International Ophthalmology·Siamak AkbarzadehDaniel F Fouladi
Nov 19, 2019·Clinical Neuropharmacology·Su-Ping WangShaomin Li
Sep 9, 2017·International Ophthalmology Clinics·Eric D Gaier, David G Hunter
Nov 12, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Luminita Tarita-NistorEsther G González
Jul 4, 2017·Restorative Neurology and Neuroscience·Micha Daniel SchoemannGeorg Michelson
Jun 16, 2018·Visual Neuroscience·Jonathan M Holmes, Dennis M Levi
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Feb 9, 2021·Restorative Neurology and Neuroscience·Luca BattagliniClara Casco
Mar 4, 2021·Seminars in Ophthalmology·Michelle M FalconeEric D Gaier

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