Prenyl-binding domains: potential targets for Ras inhibitors and anti-cancer drugs

Seminars in Cancer Biology
Yoel Kloog, Adrienne D Cox

Abstract

Ras and Rho GTPases are prominent participants in malignant transformation. They possess an essential prenyl group (farnesyl or geranylgeranyl) that endows them with membrane-tethering ability and functional specificity. Accumulating evidence suggests that prenyl groups are involved primarily in lipid-protein interactions, and recent experiments point to prenyl-binding hydrophobic pockets in proteins regulating Ras and Rho in normal cells and cancer cells. This review presents the evidence for such prenyl-binding domains as significant players in the control of Ras-like GTPases, and the emerging concept of prenyl-binding domains as potential targets for Ras inhibitors and anti-cancer drugs.

Citations

Mar 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ann M Winter-VannPatrick J Casey
May 29, 2007·ACS Chemical Biology·Amanda J KrzysiakRichard A Gibbs
Mar 27, 2009·The Journal of Organic Chemistry·James L DonelsonRichard A Gibbs
Aug 5, 2009·The Journal of Biological Chemistry·Ian Cushman, Patrick J Casey
Jun 8, 2012·The Journal of Biological Chemistry·Alexander A TokmakovShigeyuki Yokoyama
Sep 22, 2006·Antioxidants & Redox Signaling·Gary M Bokoch, Tieming Zhao
Jun 10, 2010·Future Oncology·Ernesto Bustinza-LinaresApostolia-Maria Tsimberidou
May 3, 2005·Nature Reviews. Cancer·Ann M Winter-Vann, Patrick J Casey
Apr 22, 2005·Biological Chemistry·Klaudia Giehl
May 13, 2006·Cellular and Molecular Neurobiology·Uri AsheryYoel Kloog
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Amir KraitzerMeital Zilberman
Mar 7, 2008·Bioorganic & Medicinal Chemistry Letters·Michelle MaynorRichard A Gibbs
Nov 13, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F BakkaliM Idaomar
Oct 8, 2005·Cell Motility and the Cytoskeleton·C M WellsG E Jones
Jan 20, 2006·The European Journal of Neuroscience·Stephen M Merino, Stephen Maren
Oct 16, 2012·Journal of Biomedical Materials Research. Part a·Amir KraitzerMeital Zilberman
Apr 3, 2012·European Journal of Lipid Science and Technology : EJLST·Felix AmissahNazarius S Lamango
Apr 11, 2012·Environmental Toxicology·Lambert Ayuk-TakemNazarius S Lamango
Sep 28, 2013·Biochimica Et Biophysica Acta·Jeffrey M SchappiMark M Rasenick
Jun 23, 2012·Journal of the American Chemical Society·Katrin WeiseRoland Winter
Oct 3, 2007·Cancer Chemotherapy and Pharmacology·Roni HaklaiYoel Kloog
Jul 18, 2006·Molecular & Cellular Proteomics : MCP·Karl E Krueger, Sudhir Srivastava
Jun 10, 2006·Current Opinion in Rheumatology·Pierrick G J FournierTheresa A Guise
Jan 10, 2008·The Journal of Biological Chemistry·Cristina Lopez-AlcaláNeus Agell
Jun 19, 2019·Parasites & Vectors·Jose F Garcia-BustosRobin B Gasser
Jan 25, 2011·Cancer Research·Keren FarinRonit Pinkas-Kramarski
Jan 30, 2008·The Journal of Organic Chemistry·Diwan S RawatRichard A Gibbs
Sep 3, 2010·Journal of Medicinal Chemistry·Mei-Lin GoPatrick J Casey
May 12, 2005·Journal of Agricultural and Food Chemistry·Jack N Losso, Hiba A Bawadi

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