Preoperative administration of intravenous flurbiprofen axetil reduces postoperative pain for spinal fusion surgery.

Journal of Anesthesia
Kazunori YamashitaKoji Sumikawa

Abstract

The aim of the study was to investigate postoperative analgesia and the opioid-sparing effect of the preoperative administration of intravenous flurbiprofen axetil in patients undergoing spinal fusion surgery. Thirty-six patients were randomly allocated into one of three groups. Group A received preoperative flurbiprofen axetil, 1 mg x kg(-1). Group B received postoperative flurbiprofen axetil, 1 mg x kg(-1). Group C received a placebo. All groups were given a standardized anesthesia and intravenous morphine via a patient-controlled analgesia device for postoperative analgesia. The pain score was evaluated by a visual analog scale (VAS) at 0 (T(0)), 1 (T(1)), 2 (T(2)), 6 (T(3)), 12 (T(4)), and 24 (T(5)) h after surgery, and the morphine requirement was recorded during the study period. VAS in group A was significantly lower than that in group B at T(0) and T(1). VAS in group A was significantly lower than that in group C throughout the time course after surgery. Postoperative morphine consumption in group A was significantly lower than that in groups B and C at T(0) to T(3). As compared with postoperative administration, preoperative administration of intravenous flurbiprofen axetil provides better postoperative analgesia and a...Continue Reading

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Citations

Jul 2, 2008·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Yajun XuWei Chen
Oct 1, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mitsuharu KodakaMakiko Komori
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Dec 18, 2007·Journal of Clinical Anesthesia·Suetaka NishiikeTamotsu Harada
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Jul 15, 2015·International Journal of Pharmaceutics·Lina ZhangWeisan Pan
Apr 17, 2015·BMC Veterinary Research·Denise Tabacchi FantoniAline Magalhães Ambrósio
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Jan 25, 2020·Journal of Occupational and Environmental Medicine·Kurt T HegmannJeffrey S Harris
Mar 12, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ahilan SivaganesanClinton J Devin
Oct 1, 2017·Experimental and Therapeutic Medicine·Xing-Dui MaWen-Sheng Yang
Jul 13, 2019·Current Pharmaceutical Design·Deepak AgarwalEhab Farag
Apr 7, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Yu MaoErwei Gu
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