Preoperative and adjuvant treatment of localized rectal cancer.

Current Oncology Reports
Prajnan Das, Christopher H Crane

Abstract

Although postoperative chemoradiation has a proven role in the treatment of stage II to III localized rectal cancer, recent trials have demonstrated the role of preoperative chemoradiation. A recent randomized trial has shown that preoperative chemoradiation yields higher rates of local control and sphincter preservation and lower rates of toxicity, compared with postoperative chemoradiation. Randomized trials have also shown that preoperative chemoradiation yields higher rates of pathologic complete response and local control, compared with radiotherapy alone. In this article, we review recent trials on preoperative and adjuvant therapy of localized rectal cancer. The roles of newer agents, such as capecitabine, oxaliplatin, and bevacizumab, are also discussed, and other key issues in the treatment of localized rectal cancer are reviewed.

References

Mar 14, 1991·The New England Journal of Medicine·J E KrookJ A Mailliard
Jun 6, 1985·The New England Journal of Medicine·UNKNOWN Gastrointestinal Tumor Study Group
Nov 13, 1986·The New England Journal of Medicine·H O DouglassUNKNOWN Gastrointestinal Tumor Study Group
Apr 25, 2001·American Journal of Clinical Oncology·N A JanjanJ Skibber
Sep 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jürgen DunstStefan Frings
Aug 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus RödelRolf Sauer
Apr 7, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard L GundersonRichard M Goldberg
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jun 4, 2004·The New England Journal of Medicine·Thierry AndréUNKNOWN Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC)
Jul 9, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K BujkoP Kukołowicz
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Nov 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy Whelan, Mark Levine
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J O'ConnellNicholas Petrelli
Feb 3, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ralf-Dieter HofheinzFrank Willeke
May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fairooz F KabbinavarSomnath Sarkar
May 17, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C AscheleS Monfardini
May 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Jin Cheon KimEun Kyung Choi
Jun 4, 2005·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K BujkoUNKNOWN Polish Colorectal Study Group
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Fabio Maria VecchioClaudio Coco
Jul 1, 2005·The New England Journal of Medicine·Chris TwelvesWerner Scheithauer
Jul 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-François BossetLaurence Collette
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joakim FolkessonUlf Gunnarsson
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Helgi BirgissonBengt Glimelius
Oct 13, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-P MachielsC Sempoux
Oct 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Jing JinXin-Fan Liu
Oct 26, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus RödelChristian Wittekind
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher G WillettGregory Y Lauwers
Nov 12, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A De PaoliR Rosso
Nov 15, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Glynne-JonesA C McDonald
Nov 22, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Eric FrançoisUNKNOWN Groupe Digestif de la Fédération Nationale des Centres de Lutte Contre le Cancer

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