PMID: 6967350Aug 15, 1980Paper

Preoperative and postoperative immunological evaluation of patients with colorectal cancer

Cancer
M ShafirA H Aufses

Abstract

Twenty-two patients with cancer of the colon and rectum were studied: preoperative and postoperative cell-mediated and humoral immune factors were assessed, and local concentration of immunoglobulins in tumor tissue and in normal mucosa were measured. Lymphocyte function was found to be reduced in 50% of stage A and B and 66% of stage D patients. On the other hand, when the lymphoblastogenesis was performed in the presence of normal AB plasma, a partial restoration of lymphocyte function was noted, indicating the presence of a serum blocking factor in the blood of these patients. While there was no apparent decrease of B cell subpopulation, 57% of the tested patients showed significant reduction of T lymphocytes. Marked reduction of serum immunoglobulin levels, specifically IgG and IgM, was observed preoperatively followed by a gradual return toward normal values after surgical resection of neoplastic growth. It is noteworthy that tumor tissue contained more IgG and IgA than normal mucosa. However, IgM was below detection level both in normal and tumor tissues.

References

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Citations

Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·L SchindlerH Kirchner
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·U Elsässer-BeileJ S Mönting
Dec 1, 1985·Digestive Diseases and Sciences·A E Rogers, K M Nauss
Jun 6, 2013·Surgery Today·Toshihiro HiraiYoshiyuki Yamaguchi
Oct 2, 2001·The British Journal of Surgery·A Gupta, D I Watson
Mar 15, 2000·Surgery·K OgawaT Kajiwara
Jan 5, 2011·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Brian V HoganThomas A Hughes
Jun 24, 2004·Best Practice & Research. Clinical Anaesthesiology·Bernd SidoMarkus W Büchler
Aug 1, 1986·Cancer·H W Daniell
Jan 1, 1985·Cancer Chemotherapy and Pharmacology·U F MetzgerD L Kisner

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