Preoperative angiotensin converting enzyme inhibitor usage in patients with chronic subdural hematoma: Associations with initial presentation and clinical outcome

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Marian C NeidertOliver Bozinov

Abstract

The aim of this study is to analyze the association of preoperative usage of angiotensin converting enzyme (ACE) inhibitors with the initial presentation and clinical outcome of patients with chronic subdural hematoma (cSDH). Patients treated for cSDH between 2009 and 2013 at our institution were included in this retrospective case-control study. Medical charts were reviewed retrospectively and data were analyzed using descriptive and inferential statistics. Out of 203 patients (58 females, mean age 73.2years), 53 (26%) patients were on ACE inhibitors before their presentation with cSDH. Median initial hematoma volume in individuals with ACE inhibitors (179.2±standard error of the mean [SEM] 13.0ml) was significantly higher compared to patients without ACE inhibitors (140.4±SEM 6.2ml; p=0.007). There was an increased probability of surgical reintervention in the ACE inhibitor group (12/53, 23% versus 19/153, 12%; p=0.079), especially in patients older than 80years (6/23, 26% versus 3/45, 7%; p=0.026). ACE inhibitors are associated with higher hematoma volume in patients with cSDH and with a higher frequency of recurrences requiring surgery (especially in the very old). We hypothesize that these effects are due to ACE inhibitor ...Continue Reading

References

Jul 1, 1976·Journal of Neurosurgery·H ItoH Mizukoshi
Jan 1, 1991·British Journal of Neurosurgery·A J Drapkin
Jul 1, 1989·Neurosurgery·Y KawakamiY Shimamura
Mar 15, 1967·Life Sciences·E G Erdos, H Y Yang
May 1, 1967·The Tohoku Journal of Experimental Medicine·N Watanabe
Jan 1, 1983·General Pharmacology·F MarceauJ P Giroud
Jan 25, 2002·Postgraduate Medical Journal·V AdhiyamanB K Bhowmick
Mar 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·J Sajanti, K Majamaa
Jul 9, 2004·Current Opinion in Allergy and Clinical Immunology·Mark S Dykewicz
Aug 23, 2005·Archives of Disease in Childhood·C HobbsA Seal
Oct 31, 1965·The Journal of Experimental Medicine·O D Ratnoff
Sep 13, 2011·Neurosurgical Review·Andrew F DucruetE Sander Connolly
Jul 5, 2012·Brain Injury : [BI]·Andrew Il YangUzma Samadani
Aug 7, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Gurpreet S GandhokePeter Nakaji
Jul 12, 2014·Clinical Neurology and Neurosurgery·Frantz Rom PoulsenBo Halle
Aug 12, 2014·Journal of Clinical Medicine Research·Sadaharu Tabuchi, Mitsutoshi Kadowaki

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Citations

Aug 29, 2016·World Neurosurgery·Joanna GernsbackJonathan Jagid
Jan 10, 2018·Acta neurochirurgica·Nicolai MaldanerMartin N Stienen
Jan 21, 2020·Expert Opinion on Pharmacotherapy·Jinhao HuangRongcai Jiang
Jul 21, 2020·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Premysl StejskalLumir Hrabalek
May 18, 2018·World Neurosurgery·Dana C HollUNKNOWN Dutch Chronic Subdural Hematoma Research Group (DSHR)
Mar 30, 2019·World Neurosurgery·Matheus Fernandes de Oliveira

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