Preoperative anxiolysis with minimal sedation in elderly patients: bromazepam or clorazepate-dipotassium?

Acta Anaesthesiologica Scandinavica
T ErbM C Schneider

Abstract

In elderly patients undergoing ophthalmic surgery the loss of co-operation due to over-sedation, induced by drugs given preoperatively, may jeopardise the success of microsurgery performed under regional anaesthesia. The aim of this study was to compare the psychotropic effects of bromazepam and clorazepate-dipotassium, two benzodiazepines with predominantly anxiolytic and only weak sedative action. A randomised, placebo-controlled, double-blind study was designed to include 60 patients, ASA physical status II-III, older than 60 years scheduled for ophthalmic surgery under regional anaesthesia. The patients were randomised to receive either bromazepam (3 mg) or clorazepate-dipotassium (20 mg) or placebo. The study drugs were given at 10 p.m. the night before surgery and 90 min before surgery. Using the State-Trait Anxiety Inventory (STAI), the patient's anxiety was assessed at the end of the preoperative visit, on the next morning before the study drug was given and on arrival at the operating theatre. Bromazepam induced a marked anxiolytic effect as documented by a significant reduction in the STAI State values after both applications (P<0.01). Clorazepate did not differ from placebo at any evaluation time with regard to the S...Continue Reading

References

Feb 1, 1992·Anesthesiology·W M GildF W Cheney
May 1, 1986·Anaesthesia·R Ponnudurai, J Hurdley
Sep 1, 1986·Anesthesia and Analgesia·P F White
May 1, 1987·Clinical Pharmacology and Therapeutics·H R OchsR I Shader
May 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T H Madej, R T Paasuke
Nov 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R C HamiltonL Strunin
Apr 21, 1988·The New England Journal of Medicine·A RozanskiD S Berman
Apr 1, 1984·Anaesthesia·P Chalmers, J N Horton
Jan 1, 1984·Current Medical Research and Opinion·M AnsseauS Diricq

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Citations

Nov 8, 2003·Journal of Cataract and Refractive Surgery·Thomas LaubeKlaus Peter Steuhl
Oct 23, 2012·Journal of Cataract and Refractive Surgery·Javier Moreno-MontañésMarta García-Granero
Dec 17, 2014·Singapore Dental Journal·C Strøm, L S Rasmussen
Apr 6, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Nóra KecskemétiGábor Répássy
Aug 12, 2000·Acta Anaesthesiologica Scandinavica·W CaumoM B Ferreira

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