Preoperative Breast Magnetic Resonance Imaging in Women With Local Ductal Carcinoma in Situ to Optimize Surgical Outcomes: Results From the Randomized Phase III Trial IRCIS

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Corinne BalleyguierJean-Rémi Garbay

Abstract

We evaluated the addition of breast magnetic resonance imaging (MRI) to standard radiologic evaluation on the re-intervention rate in women with ductal carcinoma in situ (DCIS) undergoing breast-conserving surgery. Women with biopsy-proven DCIS corresponding to a unifocal microcalcification cluster or a mass less than 30 mm were randomly assigned to undergo MRI or standard evaluation. The primary end point was the re-intervention rate for positive or close margins (< 2 mm) in the 6 months after randomization ( ClinicalTrials.gov identifier: NCT01112254). A total of 360 patients from 10 hospitals in France were included in the study. Of the 352 analyzable patients, 178 were randomly assigned to the MRI arm, and 174 were assigned to the control arm. In the intent-to-treat analysis, 82 of 345 patients with the assessable end point were reoperated for positive or close margins within 6 months, resulting in a re-intervention rate of 20% (35 of 173) in the MRI arm and 27% (47 of 172) in the control arm. The absolute difference of 7% (95% CI, -2% to 16%) corresponded to a relative reduction of 26% (stratified odds ratio, 0.68; 95% CI, 0.41 to 1.1; P = .13). When considering only the per-protocol population with an assessable end point...Continue Reading

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Citations

Mar 18, 2020·Radiology·Ga Young YoonEun Young Chae
May 23, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christiane K KuhlIsabelle Bedrosian
May 8, 2020·European Radiology·Francesco SardanelliGiovanni Di Leo
Jun 12, 2020·Annals of Surgical Oncology·Francesca Tamburelli, Riccardo Ponzone
Jan 24, 2020·The British Journal of Surgery
Jul 7, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Sara van BekkumPieter J Westenend
Feb 21, 2021·Cancer Treatment Reviews·Alexander BartramAmit Agrawal
Jun 18, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Trine TrammOrit Kaidar-Person
Nov 24, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean L WrightAntonio C Wolff

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