Preoperative breast MRI: reproducibility and significance of findings relevant to nipple-areolar complex involvement

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Youichi MachidaEisuke Fukuma

Abstract

Eligibility of nipple-sparing mastectomy has been expanded. The purpose of this study was to evaluate interobserver agreement regarding magnetic resonance imaging (MRI) descriptors important in determining eligibility for mastectomy, and to investigate the significance of enhancement extending to the areola concerning nipple-areolar complex (NAC) involvement. Fifty-one cases with histologically confirmed NAC involvement and 54 cases with negative NAC were enrolled. Two radiologists assessed the following factors: lesion morphology (mass or non-mass enhancement); intra-nipple bright signal; enhancement extending to the areola; abnormal nipple enhancement; and tumor-nipple distance. Factors that showed a significant association with outcome in the univariate analysis were assessed by means of multivariate analysis using a logistic regression model. Interobserver agreement between observers was assessed by calculating κ values (dichotomous variables), or intraclass correlation coefficients (ICCs; continuous variables). In multivariate analysis of the results from the two observers, tumor-nipple distance (observer 1: odds ratio [OR] 0.93; 95% confidence interval [CI] 0.88-0.99; observer 2: OR 0.89; 95% CI 0.83-0.95) and enhancement...Continue Reading

References

Aug 25, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H A CenseJ J Van Lanschot
Jul 20, 2006·World Journal of Surgery·Andrzej L KomorowskiAlberto Costa
Jun 1, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marta D'AlonzoRiccardo Ponzone
Sep 12, 2012·Annals of Surgical Oncology·Shawn T SteenArmando E Giuliano
Jul 26, 2013·AJR. American Journal of Roentgenology·Ji Yoon MoonDae Young Seo
Aug 27, 2013·Annals of Surgical Oncology·Eric C BurdgeV Suzanne Klimberg
Jun 21, 2014·American Journal of Surgery·Katherine E PorukJayant Agarwal
Jan 13, 2015·Virchows Archiv : an International Journal of Pathology·Dipti M KaramchandaniJulie Mack
Mar 18, 2015·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Naomi SakamotoKazuei Hoshi
Apr 24, 2015·AJR. American Journal of Roentgenology·Lars J GrimmSujata V Ghate
Jul 27, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Riccardo PonzoneLaura Martincich
Sep 8, 2015·The Breast : Official Journal of the European Society of Mastology·Stefano SantoroLucio Fortunato
Dec 3, 2015·Journal of Surgical Oncology·Jordan D FreyAmber A Guth
Mar 25, 2016·AJR. American Journal of Roentgenology·José Roberto Morales PiatoJosé Roberto Filassi
Jul 7, 2016·Annals of Surgical Oncology·Tracy Ann MooRache Simmons

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Citations

Sep 21, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Hirohito SekiKen Shimizu

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