Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer

Journal of Surgical Oncology
Jung Wook HuhYoung Jin Kim

Abstract

We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colon cancer. We reviewed 474 patients who underwent potentially curative resection for nonmetastatic colon cancer. Patients were categorized into two groups according to the preoperative serum CEA level: low CEA (<5 ng/ml) and high CEA (>or=5 ng/ml) groups. During the median 45-month follow-up period, the 5-year overall and disease-free survival rates for patients with a low CEA level were 81.7% and 82.4%, respectively, which were significantly higher than the rates for those with a high CEA level (69.9%; P = 0.011 and 70.6%; P = 0.002, respectively). A multivariate analysis revealed that a preoperative serum CEA level was a significant independent prognostic factor for both overall survival (P = 0.021) and disease-free survival (P = 0.026). Both the overall and disease-free survival rates in patients with stage II tumors differed significantly between the low and high CEA groups, whereas the rates did not different between those with stage I and III tumors. Preoperative serum CEA is a reliable predictor of recurrence and survival after curative surgery in patients with colon cancer, particularly in those classifie...Continue Reading

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Citations

May 1, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jung Wook HuhYoung Jin Kim
Feb 26, 2010·Annals of Surgical Oncology·Jung Wook HuhYoung Jin Kim
Apr 8, 2011·World Journal of Gastroenterology : WJG·Longxue JinKatsutoshi Kaneko
May 25, 2013·International Surgery·Satoshi HatanoIchiro Miura
Jan 15, 2014·Journal of Cancer Research and Clinical Oncology·Jung Wook HuhHo-Kyung Chun
Jul 19, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L ChenX Su
Oct 25, 2013·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Mi-Joo ChungMi-Ryeong Ryu
Jun 15, 2013·Journal of Cancer Research and Clinical Oncology·Jung Wook HuhYoung Jin Kim
Apr 7, 2012·American Journal of Surgery·Hasan T KiratRavi P Kiran
Jan 25, 2012·Journal of Magnetic Resonance Imaging : JMRI·Luís Curvo-SemedoRegina G H Beets-Tan
May 18, 2013·Journal of Surgical Oncology·Ramzi AmriDavid L Berger
Jan 13, 2012·Veterinary and Comparative Oncology·N YamadaK Maruo
Aug 13, 2014·ANZ Journal of Surgery·Jung-A YunHo-Kyung Chun
Jul 16, 2013·International Journal of Cancer. Journal International Du Cancer·M J DuffyC Sturgeon
Mar 17, 2015·International Journal of Surgery·Imran BhattiGiuseppe Garcea
May 13, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·In-Ho KimMyung Ah Lee
Nov 17, 2017·Journal of Cellular Biochemistry·Ziba Veisi MalekshahiWalead Ebrahimizadeh
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Abdullah SisikOrhan Alimoglu
Nov 5, 2014·International Journal of Colorectal Disease·Soo Young LeeHyeong Rok Kim
Mar 27, 2015·Biomarkers in Medicine·Michael J Duffy
Dec 3, 2014·The International Journal of Biological Markers·Chia-Chu ChangShih-Ching Chang

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