Abstract
Background: Preoperative hematological markers that indicate nutritional, coagulation, and inflammation statuses have prognostic value for gliomas. This study aimed to investigate hematological markers with regard to tumor grades, isocitrate dehydrogenase mutations (IDH), age, and sex in patients with gliomas. Methods: From 2008 to 2017, patients with a pathological diagnosis of glioma who underwent surgery were retrospectively enrolled in this study. Information from clinical records, including age, sex, preoperative experiment tests (routine blood tests, biochemistry, and coagulation examinations), pathological results, and IDH status, was collected. A univariable survival analysis was performed. Hematological factors such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte-ratio (PLR), and albumin-to-globulin (AGR) were calculated. The prognostic nutrition index (PNI) was calculated as 10 × serum albumin value (g/dl) + 0.005 × peripheral lymphocyte count (per mm3). Results: Our study included 706 patients. The univariate analysis showed that age, IDH-1, and hematological factors were all significantly associated with overall survival (OS) in patients with gliomas. Our results showed that inflammation markers ...Continue Reading
References
Aug 17, 1999·Journal of Neuro-oncology·J A SchwartzbaumJ L Fisher
Sep 29, 1999·Acta Neuropathologica·G FossatiM L Rossi
Mar 11, 2005·Journal of Clinical Gastroenterology·Mario Chojkier
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Mar 18, 2010·Cancer Research·Kris A SteinbrecherJoseph S Palumbo
Jun 15, 2012·Thrombosis Research·Jay L Degen, Joseph S Palumbo
Nov 19, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ji LiangJohn F de Groot
Sep 23, 2014·Future Oncology·Cristiana TanaseMonica Neagu
Feb 11, 2015·Neurologia i neurochirurgia polska·Przemyslaw ZadoraTomasz Trojanowski
Sep 6, 2015·BMC Cancer·Sheng HanAnhua Wu
Nov 26, 2015·Cancer Treatment Reviews·A PerisanidisE Nkenke
May 10, 2016·Acta Neuropathologica·David N LouisDavid W Ellison
Jul 22, 2016·Cancer Immunology, Immunotherapy : CII·Anna K KozlowskaAnahid Jewett
Nov 7, 2016·Clinical Neurology and Neurosurgery·Xing-Wang ZhouQing Mao
Jan 13, 2017·Journal of Neuro-oncology·Zhen-Qiang HeYong-Gao Mou
Feb 23, 2017·Oncotarget·Peng-Fei WangChang-Xiang Yan
Feb 23, 2017·OncoTargets and Therapy·Wen-Zhe XuYu-Guang Liu
Oct 4, 2017·Journal of breast cancer·Ki-Tae HwangSuzy Kim
Oct 28, 2017·Journal of Neuro-oncology·Marta LopesPaulo Linhares
Nov 4, 2017·Journal of Neurosurgery·Shi-Hao ZhengSheng-Yue Huang
Nov 9, 2017·Neuro-oncology·Quinn T OstromJill S Barnholtz-Sloan
Nov 10, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Louis Burt NaborsAnita Engh
Nov 11, 2017·Frontiers in Immunology·Matteo MassaraRaffaella Bonecchi
Dec 1, 2017·Journal of Cancer·Jiaxi HeJianxing He
Dec 21, 2017·Journal of Neuro-oncology·Wenshen XuLiming Huang
Jan 25, 2018·Journal of Translational Medicine·Lu-Lu YeHong-Mei Ying
Jan 26, 2018·Archives of Gynecology and Obstetrics·Zhe ZhaoHongluan Mao
Jun 7, 2018·Oncoimmunology·Zenghui QianXing Liu
Citations
Sep 25, 2019·Clinical and Translational Science·Da-Peng WangJian Hai
Aug 25, 2019·Aging·Zhen-Yu ZhangWei-Wei Wang
Feb 11, 2020·Frontiers in Oncology·Shujun LiuXixiong Kang
Jul 8, 2020·Medicine·Mingchang Liu, Liwen Wang
Dec 7, 2019·BMC Neurology·Zhenxing HuangJian Xie
Nov 17, 2020·Frontiers in Oncology·Wei WuJia Wang
Nov 25, 2020·Pituitary·Pedro MarquesAlberto M Pereira
Dec 29, 2020·Frontiers in Oncology·Chao ZhaoXin-Ting Wei
Jul 16, 2019·Clinical Neurology and Neurosurgery·Ruofei LiangYanhui Liu
Feb 9, 2021·Journal of Neurosciences in Rural Practice·Gaurav SharmaVirendra Deo Sinha
Nov 17, 2020·World Neurosurgery·Sakibul HuqDebraj Mukherjee
Feb 5, 2021·World Neurosurgery·Venkatesh S MadhugiriA Sathia Prabhu
Aug 24, 2019·World Neurosurgery·Zhaohua TanXinqiong Huang
Feb 20, 2021·Cancer Management and Research·Chao ZhaoXinting Wei
Mar 30, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hatice YılmazNezih Meydan
Jun 8, 2021·International Journal of General Medicine·Tianshu JiaZhuo Xi
Jun 2, 2021·Critical Reviews in Oncology/hematology·Alexandra Gomes Dos SantosAdilson J M de Oliveira
Jun 22, 2021·Frontiers in Oncology·Hamza AliMyron G Best
Jul 3, 2021·Pharmaceuticals·Michele StellaDavide Barbagallo
Apr 11, 2021·The Journal of Clinical Endocrinology and Metabolism·Pedro MarquesAlberto M Pereira
Sep 2, 2021·Cancer Management and Research·Ou Ying YanFeng Liu
Oct 9, 2021·Seminars in Thrombosis and Hemostasis·Anne Winther-LarsenAnne-Mette Hvas
Dec 30, 2021·Medicine·Ping YanQian-Rong Huang