Preoperative chemoradiation for rectal cancer using capecitabine and celecoxib correlated with posttreatment assessment of thymidylate synthase and thymidine phosphorylase expression.

International Journal of Radiation Oncology, Biology, Physics
Keith R UngerTyvin A Rich

Abstract

Thymidylate synthase (TS) and thymidine phosphorylase (TP) expression have been shown to be predictors of response to therapy. The toxicity, efficacy, surgical morbidity, and immunohistochemical TS and TP expression were assessed in surgical resection specimens after preoperative chemoradiation. Twenty patients with clinical stage I to III rectal adenocarcinoma received preoperative chemoradiation and underwent surgical resection 6 weeks later. Posttreatment tumor stages were T1 to T2 and N0 in 30% of patients; T3 to T4 and N0 in 30% of patients; and T1 to T3 and N1 to N2 in 15% of patients. Pathologic complete response (pCR) was evident in 25% and tumor regression occurred in a total of 80% of patients. Anal sphincter-sparing surgery was performed in 80% of cases. Acute and perioperative complications were minimal, with no grade 3/4 toxicity or treatment breaks. Pelvic control was obtained in 90% of patients. With a median follow-up of 65.5 months (range, 8-80 months), the 6-year actuarial survival rate was 75%. Local failure was significantly associated with nonresponse to therapy and with high TS and low TP expression (p = 0.008 and p = 0.04, respectively). The combination of capecitabine, celecoxib, and x-radiation therapy ...Continue Reading

References

Jan 1, 1997·International Journal of Colorectal Disease·O DworakA Hoffmann
Aug 7, 2003·American Journal of Clinical Oncology·Tyvin A Rich, Robert Shepard
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
May 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Jin Cheon KimEun Kyung Choi
Oct 11, 2005·International Journal of Radiation Oncology, Biology, Physics·Fraser M SmithM John Kennedy
Dec 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carmelo BlanquicettMartin R Johnson
Sep 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Torsten LierschChristiane Jakob

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Citations

Dec 14, 2011·International Journal of Colorectal Disease·Wendy LeeJoseph Kim
Sep 29, 2015·Expert Review of Molecular Diagnostics·Prachi M PatelSergio Huerta
Jan 1, 2014·Journal of Surgical Oncology·Ling-Wei WangTsang-Wu Liu
Aug 27, 2014·Journal of Vascular and Interventional Radiology : JVIR·Andrew C GordonRobert J Lewandowski
Sep 29, 2019·Journal of the Anus, Rectum and Colon·Gaku OhiraHisahiro Matsubara

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