Preoperative chemoradiotherapy versus surgery alone for advanced low rectal cancer: a large multicenter cohort study in Japan

Surgery Today
Tomonori AkagiMasahiko Watanabe

Abstract

To clarify the usefulness of chemoradiotherapy (CRT) for low rectal cancer, we investigated the current status of CRT in Japan and its short- and long-term outcomes versus surgery alone for low rectal cancer in a large multicenter cohort study. Between January 2010 and December 2011, data from 1608 patients with clinical Stage II-III rectal adenocarcinoma were collected from 69 specialized centers. Of these 1608 patients, 923 were diagnosed with clinical stage III low rectal cancer, 838 were enrolled in this study, divided into the surgery-alone group (n = 649) and preoperative CRT group (n = 189), and analyzed. The following parameters were significantly lower in the CRT versus surgery-alone group: blood loss (210 vs. 431.5 mL), postoperative complications (27.5% vs 39.0%), and the incidence of anastomotic leakage (3.7% vs. 8.8%). The 3-year overall survival, relapse-free and local recurrence-free survival rates did not between the two groups to a statistically significant extent (91.2% vs. 87.4%, 68.8% vs. 66.4%, and 88.2% vs. 88.4%, respectively). The present study revealed the current status of CRT for low rectal cancer in Japan. The results showed that CRT could be safely performed for advanced low rectal cancer in compari...Continue Reading

References

Jun 6, 1985·The New England Journal of Medicine·UNKNOWN Gastrointestinal Tumor Study Group
Nov 13, 1986·The New England Journal of Medicine·H O DouglassUNKNOWN Gastrointestinal Tumor Study Group
Jul 9, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K BujkoP Kukołowicz
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Sep 15, 2006·The New England Journal of Medicine·Jean-François BossetUNKNOWN EORTC Radiotherapy Group Trial 22921
Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Pierre GérardLaurent Bedenne
Mar 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Alexis UlrichMarkus W Büchler
Sep 23, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark S RohNorman Wolmark
May 25, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carlo AscheleLuca Boni
Mar 30, 2017·International Journal of Clinical Oncology·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Jun 20, 2017·Annals of Surgery·Koya HidaUNKNOWN Japan Society of Laparoscopic Colorectal Surgery
Nov 27, 2019·Journal of the Anus, Rectum and Colon·UNKNOWN Japanese Society for Cancer of the Colon and Rectum

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