Preoperative chemotherapy for cStage III-pN0 patients with non-small cell lung cancer.

The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi
Shunsuke EndoYasunori Sohara

Abstract

Survival benefits with preoperative chemotherapy for non-small cell lung cancer (NSCLC) remain controversial. Preoperative chemotherapy may act on micrometastasis but not lymph node metastasis. To clarify the role of induction chemotherapy for control of micrometastasis, we reviewed and compared 5-year follow-ups of clinical stage III but pathologically-proven node-negative NSCLC patients after complete resection with or without preoperative chemotherapy. We reviewed 148 consecutive patients who underwent anatomical lung resection and mediastinal nodal dissection for pathologically-proven node-negative NSCLC at our hospital between 1994 and 1999. Fifty-six patients were preoperatively diagnosed as stage III: 26 received platinum-based chemotherapy prior to surgery (PCT group) and 30 underwent surgery without any prior chemotherapy (PRS group). The 5-year survival rate for clinical stage I/II and pathological node-negative patients was 74.9%; for clinical stage III, but for pathological node-negative patients it was 92.3% in the PCT and 63.3% in the PRS groups. The survival benefit of preoperative chemotherapy was significant for clinical stage II patients without node involvement. Preoperative chemotherapy may provide survival ...Continue Reading

References

Jan 1, 1992·Journal of the National Cancer Institute·T Le ChevalierJ Y Douillard
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Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alain DepierreUNKNOWN French Thoracic Cooperative Group
Sep 29, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Shunsuke EndoYasunori Sohara

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Citations

Oct 19, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lioe-Fee de Geus-OeiWim J G Oyen

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