Preoperative Circulating Succinate Levels as a Biomarker for Diabetes Remission After Bariatric Surgery

Diabetes Care
Victoria Ceperuelo-MallafréSonia Fernández-Veledo

Abstract

To determine the potential use of baseline circulating succinate to predict type 2 diabetes remission after bariatric surgery. Forty-five obese patients with diabetes were randomly assigned to Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), or laparoscopic greater curvature plication. Anthropometric parameters were evaluated, and a complete biochemical analysis including circulating serum succinate concentrations was performed at baseline and 1 year after surgery. The results were externally validated in a second cohort including 88 obese patients with diabetes assigned to RYGB or SG based on clinical criteria. Succinate baseline concentrations were an independent predictor of diabetes remission after bariatric surgery. Patients achieving remission after 1 year had lower levels of baseline succinate (47.8 [37.6-64.6] µmol/L vs. 64.1 [52.5-82.9] µmol/L; P = 0.018). Moreover, succinate concentrations were significantly decreased 1 year after surgery (58.9 [46.4-82.4] µmol/L vs. 46.0 [35.8-65.3] µmol/L, P = 0.005). In multivariate analysis, the best logistic regression model showed that baseline succinate (odds ratio [OR] 11.3, P = 0.031) and the type of surgery (OR 26.4, P = 0.010) were independently associated with rem...Continue Reading

References

Apr 25, 2007·Journal of Hepatology·Paulo Renato A V CorreaMichael H Nathanson
Oct 24, 2007·American Journal of Hypertension·Nalini SadagopanMichael A Tones
Jul 1, 2008·Diabetologia·P Schrauwen, M K C Hesselink
May 23, 2009·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Brian E KaderaEric J DeMaria
Oct 31, 2009·Diabetes Care·John B BuseM Sue Kirkman
Dec 24, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S R KashyapP R Schauer
Aug 7, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Numan HamzaBasil J Ammori
Oct 1, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H AshrafianS R Bloom
Jan 29, 2011·Journal of Obesity·Simon N DankelLena Burri
Jul 23, 2011·The Journal of Clinical Endocrinology and Metabolism·M NannipieriE Ferrannini
Nov 28, 2013·Journal of Proteome Research·Hutan AshrafianThanos Athanasiou
Mar 1, 2014·The Lancet. Diabetes & Endocrinology·Christopher D StillGeorge Argyropoulos
Dec 30, 2014·Cell Communication and Signaling : CCS·Carla J AguiarM Fatima Leite
Apr 15, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Wei-Jei LeeShu-Chun Chen
Apr 15, 2015·Omics : a Journal of Integrative Biology·Thiago I B LopesAnita J Marsaioli
Nov 11, 2015·Cell Metabolism·Petia Kovatcheva-DatcharyFredrik Bäckhed
Jul 15, 2016·Cell Metabolism·Filipe De VadderGilles Mithieux
Mar 4, 2017·Endokrynologia Polska·María L Fernández-SotoFernándo Escobar-Jiménez
Mar 30, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Miriam EjarqueJoan Vendrell
Apr 6, 2017·Cell Metabolism·Anna Sofie HustedThue W Schwartz
Jun 8, 2017·The Journal of Trauma and Acute Care Surgery·Angelo DʼAlessandroAnirban Banerjee
Jul 26, 2017·Annals of Surgery·Ali AminianPhilip R Schauer
Aug 12, 2017·BMC Endocrine Disorders·Chrysi KoliakiAlexander Kokkinos
Feb 13, 2018·The ISME Journal·Carolina SerenaSonia Fernández-Veledo
Jul 20, 2018·Nature·Evanna L MillsEdward T Chouchani
Aug 20, 2018·Obesity Surgery·Luigi AngrisaniN Scopinaro

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Citations

Jul 30, 2020·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Nathan D WongJonathan Pak
Jul 30, 2020·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Christine GyldenkerneMichael Maeng
Jul 13, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Natasha Mendonça MachadoDan Linetzky Waitzberg
Jan 27, 2021·Endocrinología, Diabetes Y Nutrición·Elena González ArnáizIsidoro Cano Rodríguez
Mar 7, 2021·Free Radical Biology & Medicine·Ana VujicThomas Krieg
Feb 26, 2021·Nutrition & Diabetes·Lydia Coulter KweeBlandine Laferrère
Jul 22, 2021·Reviews in Endocrine & Metabolic Disorders·Carolina Gutiérrez-RepisoFrancisco J Tinahones
Jul 17, 2021·Endocrinología, Diabetes Y Nutrición·Elena González ArnáizIsidoro Cano Rodríguez
Jul 25, 2021·Trends in Endocrinology and Metabolism : TEM·Sonia Fernández-VeledoJoan Vendrell
Jul 29, 2021·Cardiovascular Diabetology·Francisco J Osuna-PrietoSonia Fernández-Veledo

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