PMID: 6170283Nov 1, 1981Paper

Preoperative cisplatin and bleomycin therapy in head and neck squamous carcinoma. Prognostic factors for tumor response

Archives of Otolaryngology
S R BakerG T Wolf

Abstract

A multi-institutional National Cancer Institute trial of preoperative cisplatin (100 mg/sq m, day 1) and intravenous bleomycin sulfate (15-mg/sq m bolus, day 3, followed by 15 mg/sq m/day, 24-hour infusion, days 3 to 7) was carried out in patients with previously untreated, resectable stage III and IV squamous cell carcinoma of the oral cavity or larynx and hypopharynx. Of the first 113 patients who received a single course of induction chemotherapy, eight complete responses and 47 partial responses at the primary site were observed (49%). Of 76 patients who had clinically positive regional adenopathy, 11 complete responses and 31 partial responses of neck nodes were observed (55%). The response rates of the primary tumor and the regional nodes to induction chemotherapy were assessed with respect to several pretreatment patient and tumor characteristics and to reported toxic effects after chemotherapy. Of the factors examined, no prognostic indicators were highly useful to predict the response of the primary tumor. However, the response of regional adenopathy was associated with the initial N class, the site of primary tumor, and the response of the primary tumor to induction chemotherapy.

Citations

Nov 1, 1984·The Journal of Laryngology and Otology·S BahadurS K Kacker
Mar 1, 1984·American Journal of Otolaryngology·G T Wolf
Feb 5, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ricardo HittHernán Cortes-Funes
Jan 13, 1983·The New England Journal of Medicine·W K Hong, R Bromer
Jun 1, 1986·The American Journal of the Medical Sciences·A A Forastiere
Jun 1, 1987·British Journal of Obstetrics and Gynaecology·F KirstenM Friedlander
Jun 1, 1987·Clinical Otolaryngology and Allied Sciences·J B CampbellE D Vauhan
Jul 1, 1991·Head & Neck·S FrustaciS Monfardini
Aug 1, 1986·Current Problems in Surgery·D G McQuarrie
Oct 1, 1989·American Journal of Surgery·M R Sultan, J J Coleman

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