PMID: 8600097Mar 15, 1996Paper

Preoperative concurrent chemoradiotherapy for unresectable Stage III nonsmall cell lung cancer

International Journal of Radiation Oncology, Biology, Physics
D MilsteinE Robinson

Abstract

We carried out a Phase II trial in an attempt to improve resectability and survivability of inoperable Stage III A and III B nonsmall cell lung cancer (NSCLC) patients by implementing a neoadjuvant chemoradiotherapy treatment program. Thirty-six patients with locally advanced Stage III NSCLC received neoadjuvant therapy consisting of 50.4 Gy in 5.5 weeks concurrent with two cycles of chemotherapy, using cisplatin and etoposide. No postsurgical consolidation therapy was given. Assessment at 3 to 6 weeks after treatment suggested that 26 (72%) patients had been rendered resectable. Toxicities were common but usually tolerable; however, one toxic death occurred. Of 24 patients who proceeded to thoracotomy, complete resection was achieved in 20 (56%). There were two surgically related deaths. Surgical-pathological staging showed downstaging in 18 patients, including complete sterilization of the tumor in 3 (8%). The median survival for all 36 patients is 15 months, but at the time of analysis, median survival of resectable patients had not been reached. The actuarial 2-year survival is 39% for all study groups, 57% for resectable patients, and 16% for the remaining (p < 0.005). While this preoperative neoadjuvant appears to improve...Continue Reading

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Citations

Sep 4, 1999·The Annals of Thoracic Surgery·J R SonettZ Gamliel
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J Jassem
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jocelyne MartinValerie W Rusch
Feb 5, 2000·Seminars in Surgical Oncology·G L Zorn, J C Nesbitt

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