Preoperative controlling nutritional status (CONUT) score as a novel predictive biomarker of survival in patients with localized urothelial carcinoma of the upper urinary tract treated with radical nephroureterectomy

Urologic Oncology
Hiroki IshiharaKazunari Tanabe

Abstract

The purpose of this study was to investigate the correlation between the controlling nutritional status (CONUT) score and survival of patients with localized urothelial carcinoma of the upper urinary tract treated with radical nephroureterectomy (RNU). We retrospectively enrolled 107 patients. CONUT score was calculated based on the serum albumin concentration, lymphocyte count, and total cholesterol concentration. Patients were classified into 2 groups based on CONUT score. Relapse-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) after RNU were compared between the 2 groups, and predictors of survival were analyzed using Cox proportional hazards regression models. For CONUT score, the area under the curve was 0.588 and the optimal cutoff value was 3. Twenty-four patients (22.4%) had high CONUT scores. The patients with high CONUT scores had significantly shorter 5-year RFS, CSS, and OS than did those with low CONUT scores (RFS: 50.1% vs. 66.0%; CSS: 28.1% vs. 71.7%; OS: 26.4% vs. 66.8%; all P<0.05). Results of the multivariable analysis, after adjustment for factors such as pT stage, pN stage, tumor grade, presence of lymphovascular invasion, and C-reactive protein level, revealed that CONUT score...Continue Reading

Citations

Aug 14, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Masafumi OtsukaSatoshi Fukasawa
Dec 12, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yong LiAiqin He
Apr 6, 2020·General Thoracic and Cardiovascular Surgery·Masanori HaraYoshinori Watanabe
Jun 2, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Jiaguo HuangYi Fan

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