Preoperative delta-MELD score does not independently predict mortality after liver transplantation

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Patrick G Northup, Carl L Berg

Abstract

Changes in model for end-stage liver disease (MELD) score of > or = 5 points over 30 days (delta-MELD) is an independent predictor for death in patients awaiting liver transplantation. The aim of the current study was to determine if a positive change in MELD score occurring over the 30 days immediately prior to liver transplantation was predictive of posttransplant mortality. MELD scores from the day of transplantation and 30 days prior to transplantation were calculated for 1510 UNOS patients and used to compute a delta-MELD score. Multivariate modeling determined predictors of posttransplant mortality. Patients with a preoperative delta-MELD > or = 5 had higher absolute MELD scores at transplant, shorter mean posttransplant survival and higher mortality. However, multivariate analysis showed that none of the excess mortality was attributable to the high delta-MELD score (p = 0.43 for delta-MELD > or = 5) and the majority of the excess risk was attributable to absolute MELD score (p < 0.001) at the time of transplantation. Mortality of patients with rapidly worsening chronic liver disease who undergo transplantation depends substantially on absolute MELD score at the time of transplantation but not the rate of change immediat...Continue Reading

References

Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MalinchocP C ter Borg
Feb 15, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P S KamathW R Kim
Jul 19, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R H WiesnerW R Kim
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga ChalasaniJianzhao Shen
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marina BerenguerJoaquín Berenguer
Jan 4, 2003·Gastroenterology·Russell WiesnerUNKNOWN United Network for Organ Sharing Liver Disease Severity Score Committee
Jan 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Robert M MerionPhilip J Held
Jan 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nicholas N OnacaGoran B Klintmalm
May 13, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sammy SaabRonald W Busuttil
May 13, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paul J ThuluvathRichard E Thompson
May 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nicholas N OnacaGoran B Klintmalm
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paul H HayashiJames F Trotter
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hugo R RosenPeter Neuhaus
Sep 2, 2003·Transplantation Proceedings·G CatalanoF Filipponi
Jan 6, 2004·Clinical Transplantation·Itxarone BilbaoCarlos Margarit
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francis Y YaoJohn P Roberts
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Walter K KremersRussell H Wiesner

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Citations

Mar 15, 2005·Journal of Hepatology·Evangelos CholongitasAndrew K Burroughs
Jan 24, 2006·Lancet·Andrew K BurroughsUNKNOWN European Liver Transplant Association
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yuhuang WangChad A Mirkin
Mar 1, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Alastair L YoungK Rajendra Prasad
Jul 10, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Xiao XuShu-Sen Zheng
Sep 14, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Dave CollettJames Neuberger
Nov 4, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Matthew R FoxtonMichael A Heneghan
Jul 11, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Georg P GyöriGabriela A Berlakovich
Mar 13, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Jordi Colmenero, Miquel Navasa
Jan 28, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Georg P GyöriUNKNOWN Eurotransplant
Sep 23, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Clara T NicolasWalter K Kremers
Jan 2, 2018·International Journal of Critical Illness and Injury Science·Ashok Kumar PannuCharanpreet Singh
Jun 24, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Matthew JacobJan H P van der Meulen
Nov 1, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Stefano Ginanni CorradiniLuigi Iuliano
Feb 25, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Neal R BarshesJohn A Goss
Mar 22, 2006·Current Opinion in Gastroenterology·Adnan Said, Michael R Lucey
May 19, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Hannah K SmalleyMatthew J Kuehnert
Jun 1, 2013·Hepatology International·Thomas Schiano
Jan 11, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Shunji NagaiDilip Moonka
Jun 27, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ben F J GoudsmitHein Putter

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