Preoperative endovascular brain mapping for intraoperative volumetric image guidance: preliminary concept and feasibility in animal models

Journal of Neurosurgery
Robert A MericleSwadeshmukul Santra

Abstract

The authors describe a novel concept for brain mapping in which an endovascular approach is used, and they demonstrate its feasibility in animal models. The purpose of endovascular brain mapping is to delineate clearly the nonfunctional brain parenchyma when a craniotomy is performed for resection. The nonfunctional brain will be stained with sharp visual margins, differentiating it from the functional, nonstained brain. The authors list four essential criteria for developing an ideal endovascular mapping agent, and they describe seven potential approaches for accomplishing a successful endovascular brain map. Four Sprague-Dawley rats and one New Zealand white rabbit were used to determine initial feasibility of the procedure. The animals were anesthetized, and the internal carotid artery was catheterized. Four potential brain mapping agents were infused into the right hemisphere of the five animals. Afterward, the brains were removed and each was analyzed both grossly and histologically. Fluorescein and FD&C Green No. 3 provided good visual clarity and margins, but required blood-brain barrier (BBB) manipulation. Tantalum particles enabled avoidance of BBB manipulation, but provided inadequate visual clarity, probably because ...Continue Reading

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Citations

Aug 1, 2012·Radiology Research and Practice·Ioannis Z KapsalakisKostas N Fountas
Feb 10, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·YouRong Sophie SuOmar Choudhri
Aug 22, 2008·Neurosurgery·L Nelson Hopkins, Robert D Ecker

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Methods Mentioned

BETA
electron microscopy
PCA
sedation

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