Preoperative estimated glomerular filtration rate predicts overall mortality in patients undergoing radical prostatectomy

Urologic Oncology
Matthew K TollefsonR Jeffrey Karnes

Abstract

Assessment of overall health is a critical component in the evaluation of patients presenting with clinically localized prostate cancer. Estimated glomerular filtration rate (eGFR) has been associated with increased risk of cardiovascular and overall mortality. Therefore, the objective of our study was to evaluate the impact of baseline renal function on oncologic outcomes and overall survival following radical prostatectomy. We identified 10,099 patients who underwent radical prostatectomy at our institution from 1990 to 2004 with a preoperative serum creatinine available for analysis. eGFR was calculated by the chronic kidney disease-epidemiology formula (CKD-EPI) and reported as ml/min per 1.73 m(2). Patients were then classified according to their eGFR: <30, 30-59, 60-89, 90-119, and 120-150 ml/min/1.73 m(2). Multivariate Cox proportional hazard regression models were used to analyze the impact of eGFR on postoperative outcomes. At the time of surgery, 25 patients (0.1%) had an eGFR <30 ml/min/1.73 m(2), 2,398 (23.7%) between 30 and 60, 7,097 (70.3%) between 60 and 90, and 605 (6.0%) patients had an eGFR >90. eGFR was not associated with oncologic outcomes, including biochemical recurrence, systemic progression or cancer-sp...Continue Reading

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Citations

Jul 22, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Marianne SchmidQuoc-Dien Trinh
Apr 30, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jacek B CywinskiDaniel I Sessler
Nov 5, 2013·The Medical Clinics of North America·Alicia Gruber Kalamas, Claus U Niemann

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