Abstract
Assessment of overall health is a critical component in the evaluation of patients presenting with clinically localized prostate cancer. Estimated glomerular filtration rate (eGFR) has been associated with increased risk of cardiovascular and overall mortality. Therefore, the objective of our study was to evaluate the impact of baseline renal function on oncologic outcomes and overall survival following radical prostatectomy. We identified 10,099 patients who underwent radical prostatectomy at our institution from 1990 to 2004 with a preoperative serum creatinine available for analysis. eGFR was calculated by the chronic kidney disease-epidemiology formula (CKD-EPI) and reported as ml/min per 1.73 m(2). Patients were then classified according to their eGFR: <30, 30-59, 60-89, 90-119, and 120-150 ml/min/1.73 m(2). Multivariate Cox proportional hazard regression models were used to analyze the impact of eGFR on postoperative outcomes. At the time of surgery, 25 patients (0.1%) had an eGFR <30 ml/min/1.73 m(2), 2,398 (23.7%) between 30 and 60, 7,097 (70.3%) between 60 and 90, and 605 (6.0%) patients had an eGFR >90. eGFR was not associated with oncologic outcomes, including biochemical recurrence, systemic progression or cancer-sp...Continue Reading
References
Jul 1, 1996·The Journal of Urology·P C AlbertsenJ Fine
Jul 18, 1996·The New England Journal of Medicine·N A Christakis, J J Escarce
Mar 13, 1999·Annals of Internal Medicine·A S LeveyD Roth
May 31, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony V D'AmicoMing-Hui Chen
Mar 17, 2004·The Journal of Urology·Ashutosh TewariMani Menon
Apr 22, 2004·Journal of the American Society of Nephrology : JASN·Daniel E WeinerMark J Sarnak
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
May 11, 2005·Kidney International·Andrew S LeveyGarabed Eknoyan
May 20, 2005·The New England Journal of Medicine·Michael G ShlipakCatherine Stehman-Breen
Jun 1, 2005·Palliative Medicine·Pietro ToscaniCarlo Peruselli
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Linda F FriedAnne B Newman
Jan 13, 2006·The Journal of Urology·Mark E CowenMichael W Kattan
Mar 15, 2006·Cancer·David L BoulosSusan L Rohland
Oct 28, 2006·Clinical Chemistry·Andrew S LeveyThomas Hostetter
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jochen WalzPierre I Karakiewicz
Sep 2, 2008·Nephron. Clinical Practice·Heidi J CoxEric S Kilpatrick
Jan 28, 2009·Journal of Pain and Symptom Management·Francis LauJu Yang
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jun 11, 2009·Journal of the National Cancer Institute·Matthew R CooperbergPeter R Carroll
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J StephensonPeter T Scardino
Sep 29, 2009·European Journal of Internal Medicine·Michael G ClarkeA L Widdison
May 21, 2010·Lancet·UNKNOWN Chronic Kidney Disease Prognosis ConsortiumRon T Gansevoort
Aug 24, 2010·European Urology·Giovanni LughezzaniAndrew J Vickers
Nov 4, 2010·JAMA : the Journal of the American Medical Association·Susan L MitchellMichele L Shaffer
Feb 22, 2011·BMJ : British Medical Journal·Janice Hopkins Tanne
Mar 30, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T HølmebakkA Nesbakken
Apr 13, 2011·JAMA : the Journal of the American Medical Association·Carmen A PeraltaDavid Warnock
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Citations
Jul 22, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Marianne SchmidQuoc-Dien Trinh
Apr 30, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jacek B CywinskiDaniel I Sessler
Nov 5, 2013·The Medical Clinics of North America·Alicia Gruber Kalamas, Claus U Niemann
Oct 17, 2017·Oncotarget·Ho Song YuJun Cheon
Apr 11, 2019·Molecular and Clinical Oncology·Kenji KurodaKeiichi Ito
Jul 25, 2019·BMC Nephrology·Chen NingYichen Zhu