PMID: 7545291Jun 10, 1995Paper

Preoperative evaluation of cancers of the esophagus. Contribution of in vivo staining

La Presse médicale
G MassardG Morand

Abstract

We assessed the effectiveness of a dye-endoscopy to detect inapparent multicentric carcinomas of the oesophagus. The study included 95 patients scheduled for oesophagectomy. A lugol stain was applied to the oesophageal mucosa and any non-stained area was biopsied. The proximal oesophagus was reexamined on the pathology specimen obtained after oesophagectomy. Intramucosal epithelioma of the proximal oesophagus was found in 7 patients (7.4%) and severe dysplasia was seen in 3 (3.1%). Abnormal stains were seen in 33 patients including 9 with diffuse parakeratosis. There were 24 focal anomalies including 6 cases of intramucosal carcinoma, 3 severe dysplasias, 3 gastric metaplasias and 12 parakeratoses. One intramucosal epithelioma observed on the surgical specimen had not been detected by the staining technique. Overall sensitivity was 85.7% and specificity was 71.7%. Including focal anomalies only, specificity was 79.5%. Vital staining is a useful tool for pre-operative assessment of cancer of the oesophagus, in particular for superficial forms.

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