Preoperative Fasting C-Peptide Predicts Type 2 Diabetes Mellitus Remission in Low-BMI Chinese Patients After Roux-en-Y Gastric Bypass

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Lei ZhaoShaihong Zhu

Abstract

This study investigated the role of preoperative fasting C-peptide (FCP) levels in predicting diabetic outcomes in low-BMI Chinese patients following Roux-en-Y gastric bypass (RYGB) by comparing the metabolic outcomes of patients with FCP > 1 ng/ml versus FCP ≤ 1 ng/ml. The study sample included 78 type 2 diabetes mellitus patients with an average BMI < 30 kg/m2 at baseline. Patients' parameters were analyzed before and after surgery, with a 2-year follow-up. A univariate logistic regression analysis and multivariate analysis of variance between the remission and improvement group were performed to determine factors that were associated with type 2 diabetes remission after RYGB. Linear correlation analyses between FCP and metabolic parameters were performed. Patients were divided into two groups: FCP > 1 ng/ml and FCP ≤ 1 ng/ml, with measured parameters compared between the groups. Patients' fasting plasma glucose, 2-h postprandial plasma glucose, FCP, and HbA1c improved significantly after surgery (p < 0.05). Factors associated with type 2 diabetes remission were BMI, 2hINS, and FCP at the univariate logistic regression analysis (p < 0.05). Multivariate logistic regression analysis was performed then showed the results were mo...Continue Reading

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Citations

Jun 27, 2019·Endocrine Reviews·Jonathan D DourosDavid A D'Alessio
Nov 26, 2020·Revista do Colégio Brasileiro de Cirurgiões·Giulia MarchettiElias Jirjoss Ilias
Jan 26, 2021·International Journal of Endocrinology·Yufang LuoZhaohui Mo
Jul 10, 2021·Journal of Molecular Cell Biology·Yinfang TuPin Zhang

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