Preoperative Functional Platelet Number Is Inversely Associated With 30-Day Mortality After Cardiac Surgery: A Retrospective Cohort Study.

Seminars in Cardiothoracic and Vascular Anesthesia
Soutik GhosalJiapeng Huang

Abstract

Background. We hypothesize that preoperative functional platelet number (platelet count multiplied by platelet aggregation percentage) are associated with 30-day mortality after cardiac surgery. Methods. We linked our preoperative testing database with the STS (Society of Thoracic Surgeon) database to form a study cohort of 1390 patients who had cardiac surgeries between January 2008 and December 2013. Preoperative tests of platelet count and platelet aggregation were routinely performed on all cardiac surgical patients within 24 hours before entering the operating room. Multiple logistic regression models were used to determine whether functional platelet number are associated with 30-day mortality, modified composite major adverse cardiocerebral events, postoperative renal failure or requirement for new renal replacement therapy, and reoperation for bleeding. Log-linear models were used to examine whether functional platelet numbers are associated with hospital length of stay and intensive care unit length of stay. Results. Functional platelet number had an inverse association with 30-day mortality, and each 50 × 109/L increase in functional platelet number resulted in decreased 30-day mortality (odds ratio of 0.767 with 95% ...Continue Reading

References

Dec 6, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Reija MikkolaFausto Biancari
Mar 21, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Fausto BiancariJouni Heikkinen
Apr 13, 2013·British Journal of Anaesthesia·T JohanssonA C Sönnichsen
Dec 3, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Seema AgarwalMatthew Shaw
Apr 29, 2015·The Annals of Thoracic Surgery·Jiapeng HuangMark S Slaughter
May 2, 2017·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerKai Zacharowski
Oct 17, 2017·Journal of Cardiothoracic and Vascular Anesthesia·UNKNOWN Task Force on Patient Blood Management for Adult Cardiac Surgery of the European Association for Cardio-Thoracic Surgery (EADomenico Pagano
Dec 6, 2017·Journal of Cardiac Surgery·Sleiman Sebastian Aboul-HassanRomuald Cichon

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Citations

Nov 10, 2020·Seminars in Cardiothoracic and Vascular Anesthesia·Samuel GillilandNathaen Weitzel
May 25, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Brian A BrucknerRoberto J Manson

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