Preoperative Heart Rate Variability as Predictors of Vagus Nerve Stimulation Outcome in Patients with Drug-resistant Epilepsy

Scientific Reports
Hongyun LiuLuming Li

Abstract

Vagus nerve stimulation (VNS) is an adjunctive treatment for drug-resistant epilepsy (DRE). However, it is still difficult to predict which patients will respond to VNS treatment and to what extent. We aim to explore the relationship between preoperative heart rate variability (HRV) and VNS outcome. 50 healthy control subjects and 63 DRE patients who had received VNS implants and had at least one year of follow up were included. The preoperative HRV were analyzed by traditional linear methods and heart rhythm complexity analyses with multiscale entropy (MSE). DRE patients had significantly lower complexity indices (CI) as well as traditional linear HRV measurements than healthy controls. We also found that non-responders0 had significantly lower preoperative CI including Area 1-5, Area 6-15 and Area 6-20 than those in the responders0 while those of the non-responders50 had significantly lower RMSSD, pNN50, VLF, LF, HF, TP and LF/HF than the responders50. In receiver operating characteristic (ROC) curve analysis, Area 6-20 and RMSSD had the greatest discriminatory power for the responders0 and non-responders0, responders50 and non-responders50, respectively. Our results suggest that preoperative assessment of HRV by linear and M...Continue Reading

References

Aug 23, 2002·Physical Review Letters·Madalena CostaC-K Peng
Sep 25, 2002·Neurology·J Ben Renfroe, James W Wheless
Nov 26, 2002·Clinical Neurology and Neurosurgery·Paolo TanganelliGiovanni Regesta
Jun 7, 2003·Epilepsy & Behavior : E&B·Severine M ChavelSusan Spencer
Jul 28, 2004·Seizure : the Journal of the British Epilepsy Association·Douglas Labar
Feb 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J JanszkyA Ebner
Mar 24, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Madalena CostaC-K Peng
Jan 14, 2010·Epilepsia·Cristian Sevcencu, Johannes J Struijk
Apr 20, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tomoyuki MizunoYuji Wada
Aug 7, 2010·Seizure : the Journal of the British Epilepsy Association·K Jansen, L Lagae
Oct 16, 2010·Journal of Applied Physiology·Brad ManorLewis A Lipsitz
Jun 7, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ana CatarinoHoward Ring
Aug 16, 2011·Journal of Neurosurgery·Dario J EnglotKurtis I Auguste
Sep 24, 2011·Neurosurgery Clinics of North America·Dario J EnglotKurtis I Auguste
Apr 3, 2013·Clinical EEG and Neuroscience·Chen-Chih ChungChaur-Jong Hu
Dec 7, 2013·Journal of Child Neurology·Ravindra AryaKatherine D Holland
Dec 19, 2013·Epilepsy Currents·J Engel
Jul 12, 2014·Annual Review of Biomedical Engineering·David J Mogul, Wim van Drongelen
Jul 24, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Sung-Chun TangMing-Fong Chen
Sep 28, 2014·Lancet·Solomon L MoshéTorbjörn Tomson
May 1, 2015·Neurologia Medico-chirurgica·Takamichi Yamamoto
Aug 19, 2015·Scientific Reports·Yen-Hung LinChung-Kang Peng
Jun 22, 2016·Scientific Reports·Yen-Hung LinChung-Kang Peng
Jun 28, 2016·Journal of Integrative Neuroscience·Ricardo Zavala-YoeLuz M Cordero
Apr 22, 2017·Seizure : the Journal of the British Epilepsy Association·Janneke HilderinkCecile C de Vos

❮ Previous
Next ❯

Citations

Sep 12, 2018·Cold Spring Harbor Perspectives in Medicine·Bruno BonazSonia Pellissier
Jan 9, 2020·The International Journal of Neuroscience·Jinbiao XiongQing Yu
Jan 11, 2021·Brain Stimulation·Marius KeuteAlireza Gharabaghi
Jun 15, 2019·Entropy·Mohammed El-YaagoubiJosé Luis Rojo-Álvarez
Feb 27, 2021·Seizure : the Journal of the British Epilepsy Association·Stephanie HödlKristl Vonck
Mar 6, 2021·Current Opinion in Neurology·Shobi Sivathamboo, Piero Perucca
Oct 30, 2020·Seizure : the Journal of the British Epilepsy Association·Dènahin Hinnoutondji ToffaDang Khoa Nguyen
Oct 16, 2021·Neurology·Shobi SivathambooUNKNOWN MS-BioS Study Group

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.