Preoperative high-dose atorvastatin for prevention of atrial fibrillation after cardiac surgery: a randomized controlled trial.

The Journal of Thoracic and Cardiovascular Surgery
Antonios KourliourosMarjan Jahangiri

Abstract

The preventative effect of statins on postoperative atrial fibrillation has been hypothesized. However, all studies to date have examined patients who did not receive statins before their further allocation to treatment or no treatment. Because guidelines recommend the routine use of statins in patients with coronary artery disease, we set out to examine the effect of intensive statin pretreatment versus continuation of usual statin dose on atrial fibrillation after cardiac surgery. Patients receiving routine statin treatment and undergoing coronary artery bypass surgery or aortic valve replacement with no history of atrial fibrillation or antiarrhythmic medication were randomized to receive atorvastatin 80 mg or atorvastatin 10 mg for 7 days before surgery in a single-blind fashion. The primary end point was the development of postoperative atrial fibrillation during hospital stay. A total of 104 consecutive patients were included. Postoperative atrial fibrillation occurred in 33 patients (32.4%). No significant differences were found in demographics, medical history, or intraoperative variables between treatment groups, with the exception of higher rate of β-blocker use in the atorvastatin 10 mg group (75% vs 53%, P = .002) a...Continue Reading

References

Dec 1, 1991·Statistics in Medicine·D G Altman
Nov 14, 2000·The American Journal of Cardiology·M I DotaniC M Gibson
Dec 17, 2003·The American Journal of Cardiology·Yinong Young-XuShmuel Ravid
Sep 11, 2004·Journal of the American College of Cardiology·Scott M GrundyUNKNOWN Coordinating Committee of the National Cholesterol Education Program
Dec 27, 2005·The American Journal of Cardiology·Francisco MarínMariano Valdés
Feb 5, 2008·The Journal of Thoracic and Cardiovascular Surgery·Kirkeith LertsburapaCraig I Coleman
Apr 30, 2008·The Annals of Thoracic Surgery·Antonios KourliourosMarjan Jahangiri
Oct 1, 2008·Circulation·Giovanni MariscalcoAndrea Sala
Oct 29, 2008·The Journal of Thoracic and Cardiovascular Surgery·Antonios KourliourosMarjan Jahangiri
Jun 23, 2009·Current Vascular Pharmacology·Maciej BanachOttavio Alfieri
Aug 25, 2009·The Journal of Thoracic and Cardiovascular Surgery·Oliver J LiakopoulosThorsten Wahlers

❮ Previous
Next ❯

Citations

Feb 25, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Irene SavelievaA John Camm
Apr 26, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Irene SavelievaA John Camm
Sep 22, 2011·Current Opinion in Cardiology·Alexander Kulik, Marc Ruel
Aug 21, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Mark PullanMichael Poullis
Jan 7, 2014·European Journal of Clinical Investigation·Kirolos A JacobDiederik van Dijk
Mar 4, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giuseppe PattiKausik K Ray
May 25, 2016·The Cochrane Database of Systematic Reviews·Elmar W KuhnOliver J Liakopoulos
Mar 12, 2015·The Cochrane Database of Systematic Reviews·Michelle LewickiAntoine G Schneider
Aug 19, 2015·Journal of the American Heart Association·Michael GoldfarbJonathan Afilalo
Mar 4, 2021·Journal of Cardiovascular Development and Disease·Homa NomaniAmirhossein Sahebkar
Jun 16, 2021·The Journal of Arthroplasty·John C BonanoDerek F Amanatullah
Mar 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Adriana Correa MeloSamuel Santos Valença

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.