Preoperative hydration with 0.9% normal saline to prevent acute kidney injury after major elective open abdominal surgery: A randomised controlled trial

European Journal of Anaesthesiology
Ana B SerranoFernando Liaño

Abstract

Postoperative acute kidney injury (AKI) is the second leading cause of hospital-acquired AKI. Although many preventive strategies have been tested, none of them has been totally effective. We investigated whether preoperative intravenous hydration with 0.9% normal saline could prevent postoperative AKI. Randomised controlled trial. University Ramón y Cajal Hospital, Spain, from June 2006 to February 2011. Total 328 inpatients scheduled for major elective open abdominal surgery. 0.9% normal saline at a dose of 1.5 ml kg h for 12 h before surgery. The primary outcome was the overall postoperative AKI incidence during the first week after surgery defined by risk, injury, failure, loss, end-stage kidney disease (RIFLE) and AKI network (AKIN) creatinine criteria. Secondary endpoints were the need for ICU admission, renal replacement therapy during the study period and adverse events and hospital mortality during hospital admission. There was no difference in the incidence of AKI between groups: 4.7% in the normal saline group versus 5.0% in the control group and 11.4% in the 0.9% normal saline group versus 7.9% in the control group as assessed by the RIFLE and AKIN creatinine criteria, respectively. Absolute risk reductions (95% con...Continue Reading

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Citations

Aug 19, 2017·Current Opinion in Critical Care·Suvi T Vaara, Rinaldo Bellomo
Nov 30, 2016·European Journal of Anaesthesiology·Ana B SerranoFernando Liaño
Nov 3, 2016·QJM : Monthly Journal of the Association of Physicians·S BellC Isles
Nov 30, 2016·European Journal of Anaesthesiology·Javier Ripollés-MelchorJosé María Calvo-Vecino
Mar 2, 2017·European Journal of Anaesthesiology·Michelle S Chew, Bernhard Walder
Mar 2, 2017·European Journal of Anaesthesiology·Ana B SerranoFernando Liaño
Mar 2, 2017·European Journal of Anaesthesiology·Hans-Joachim Priebe

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