PMID: 11316540Apr 24, 2001Paper

Preoperative hyperfractionated radiotherapy with concurrent chemotherapy in resectable esophageal cancer

International Journal of Radiation Oncology, Biology, Physics
J H KimY I Min

Abstract

To evaluate the local control rates, survival rates, and patterns of failure for esophageal cancer patients receiving preoperative concurrent chemotherapy and hyperfractionated radiotherapy followed by esophagectomy. From May 1993 through January 1997, 94 patients with resectable esophageal cancers received continuous hyperfractionated radiation (4,800 cGy/40 fx/4 weeks), with concurrent FP chemotherapy (5-FU 1 g/m(2)/day, days 2-6, 30-34, CDDP 60 mg/m(2)/day, days 1, 29) followed by esophagectomy 3-4 weeks later. If there was evidence of disease progression on preoperative re-evaluation work-up, or if the patient refused surgery, definitive chemoradiotherapy was delivered. Minimum follow-up time was 2 years. RESULTS; All patients successfully completed preoperative treatment and were then followed until death. Fifty-three patients received surgical resection, and another 30 were treated with definitive chemoradiotherapy. Eleven patients did not receive further treatment. Among 91 patients who received clinical reevaluation, we observed 35 having clinical complete response (CR) (38.5%). Pathologic CR rate was 49% (26 patients). Overall survival rate was 59.8% at 2 years and 40.3% at 5 years. Median survival time was 32 months. ...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·B KavanaghG Montana
Jan 1, 1991·International Journal of Radiation Oncology, Biology, Physics·L R CoiaG E Hanks
Jan 1, 1988·International Journal of Radiation Oncology, Biology, Physics·H G SeydelJ Tschan
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Apr 16, 1998·International Journal of Radiation Oncology, Biology, Physics·M MurakamiH Takeda

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Citations

Jun 26, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Carlo CastoroErmanno Ancona
Jun 24, 2004·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Q YangT-T Wu
Dec 4, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y KinoshitaG Watanabe
Jun 26, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M MiyashitaK Yamashita
Mar 15, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Esther van Meerten, Ate van der Gaast
Jul 21, 2010·The British Journal of Surgery·E F W Courrech StaalJ W van Sandick

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