PMID: 9527262Apr 4, 1998Paper

Preoperative idoxuridine and radiation for large soft tissue sarcomas: clinical results with five-year follow-up

Annals of Surgical Oncology
V K SondakT S Lawrence

Abstract

Local control remains an important issue in the management of large soft tissue sarcomas. Radiation is the main adjuvant to surgery for local therapy of sarcomas, but it requires relatively high doses, hitherto considered prohibitive in areas such as the retroperitoneum. We developed a preoperative treatment approach to large soft tissue sarcomas that would deliver a high total dose of radiation administered in conjunction with the halogenated pyrimidine radiosensitizer idoxuridine (IdUrd). Thirty-seven patients with large sarcomas of the head and neck, mediastinum, retroperitoneum, or extremity received three or five cycles of sequential IdUrd infusion (1000-1600 mg/m2/d x 5 d) alternating weekly with twice daily radiation (125-150 cGy per dose) and were then evaluated for resection. The delivered preoperative radiation dose was up to 6250 to 7500 cGy. Five patients (14%) had a partial response to preoperative therapy, and 28 of 37 patients underwent successful resection. There were no intra- or postoperative deaths. Local control was achieved in 19 of 28 resected patients, but in only 1 of 6 patients who remained unresectable despite therapy. With a median follow-up of 5.8 years, 28% of patients are alive with no evidence of ...Continue Reading

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Citations

Apr 5, 2000·AJR. American Journal of Roentgenology·A K GuptaM Korobkin
Dec 9, 2008·International Journal of Radiation Biology·C RebischungJ Balosso
Aug 24, 2007·Expert Opinion on Investigational Drugs·Muhammad Wasif SaifTimothy James Kinsella
Oct 25, 2013·Journal of Surgical Oncology·David E Gyorki, Murray F Brennan
Jul 4, 2002·Annals of Surgical Oncology·Peter W T PistersShreyaskumar R Patel
Aug 15, 2003·World Journal of Gastroenterology : WJG·Xiao-Hong OuYu-Guo Zhong
Oct 28, 2016·Cancer Chemotherapy and Pharmacology·Michael J Nathenson, Edward Sausville
Nov 19, 2004·Radiation Research·S CecchiniD J Hunting
Feb 14, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shivaani KummarJerry M Collins
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuji SeoTimothy J Kinsella
Feb 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Timothy J Kinsella
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuji SeoTimothy J Kinsella
Dec 13, 2005·Cancer Treatment Reviews·Simone MocellinDonato Nitti
Jul 25, 2006·Current Problems in Surgery·Christopher A GarcesWilliam G Cance
Oct 26, 2001·Seminars in Radiation Oncology·S E Berry, T J Kinsella

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