Preoperative irradiation potentiation with cisplatin: effect on rate of wound infection

American Journal of Surgery
W D MorainC T Coughlin

Abstract

Platinum coordination complexes, such as cisplatin, potentiate the cytotoxicity of irradiation on squamous cell carcinoma and certain other solid tumors. Using a rat oro-cutaneous fistula model, an investigation was carried out to determine whether or not there was a concomitant potentiation with cisplatin of the deleterious effect of preoperative irradiation on the ability of a subsequent wound to handle a bacterial challenge. Auto-contaminated wounds were found to have increased rates of infection at single-dose orthovoltage pretreatments of 1,500 rads or more. Using quantitative bacteriologic techniques, would infection was found to be no more frequent after platinum-enhanced irradiation than after irradiation alone; however, there was the additive effect of weight loss associated with combined cisplatin treatment and irradiation.

References

Aug 1, 1979·International Journal of Radiation Oncology, Biology, Physics·E B DoupleM E Tulloh
Sep 1, 1985·International Journal of Radiation Oncology, Biology, Physics·F Ellis
May 1, 1985·International Journal of Radiation Oncology, Biology, Physics·C T Coughlin, R C Richmond

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Citations

Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·J BiertJ Hoogenhout
Oct 1, 1988·Tropical Doctor·W E Schlabach
Mar 1, 1993·The Journal of Laryngology and Otology·K A Abu SharaS Z Saleh
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·C T CoughlinR L Page

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