PMID: 2512169Nov 1, 1989Paper

Preoperative irradiation with and without chemotherapy (MFL) in the treatment of primarily non-resectable adenocarcinoma of the rectum. Results from two consecutive studies

European Journal of Cancer & Clinical Oncology
G FrykholmL Påhlman

Abstract

Twenty-one consecutive patients with primarily non-resectable adenocarcinoma of the rectum were treated with preoperative split-course radiotherapy (40 Gy) and simultaneous sequential methotrexate + 5-fluorouracil + leucovorin (MFL). An initial infusion of methotrexate (250 mg/m2) was followed in the 2nd hour by 5-FU--first a bolus injection (10 mg/kg) and then continuous infusion (35 mg/kg/24 h) for 72 h. Leucovorin rescue (15 mg every 6 h) was initiated 24 h after the initial injection. Radiotherapy (10 Gy) was given with two 2.0 Gy fractions on days 1 and 2, and one fraction on day 3. The toxicity of the treatment was mostly mild to moderate. Compared with a previous consecutive series comprising 38 patients who received preoperative irradiation (greater than or equal to 40 Gy) only, with a resectability rate of 34%, the 71% resectability rate with this treatment seems to be superior.

References

Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·B UllmanD V Santi
Sep 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H von der Maase
Jan 1, 1985·Acta Radiologica. Oncology·L PåhlmanB Adalsteinsson
Jan 1, 1988·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G G Steel
Jan 1, 1987·Seminars in Surgical Oncology·N Kemeny
Mar 1, 1986·European Journal of Cancer & Clinical Oncology·B GlimeliusE Ståhle
Nov 1, 1983·International Journal of Radiation Oncology, Biology, Physics·L L GundersonH D Suit
Jan 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M OvergaardA Sell
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J E ByfieldF Kulhanian
Aug 1, 1982·International Journal of Radiation Oncology, Biology, Physics·B EmamiH H Miller
Jul 1, 1980·Diseases of the Colon and Rectum·T Bjerkeset, O Dahl
Sep 1, 1954·Cancer·M W STEARNS, G E BINKLEY

❮ Previous
Next ❯

Citations

Mar 1, 1995·World Journal of Surgery·B J Cummings
Mar 1, 1993·Diseases of the Colon and Rectum·M B NielsenJ Christiansen
Jul 1, 1996·Diseases of the Colon and Rectum·W GrafL Påhlman
Mar 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G J FrykholmB Glimelius
Feb 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G J FrykholmB Glimelius
Aug 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L CioniniF Tonelli
Apr 1, 1996·Seminars in Roentgenology·B W Loggie
Dec 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·U IsacssonB Glimelius
May 31, 2001·International Journal of Radiation Oncology, Biology, Physics·G J FrykholmB Glimelius
Jun 29, 2001·International Journal of Radiation Oncology, Biology, Physics·M El-MaltP Pattyn
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·B D MinskyJ Conti
Apr 16, 1998·International Journal of Radiation Oncology, Biology, Physics·V ValentiniM Cosimelli
Sep 25, 1998·International Journal of Radiation Oncology, Biology, Physics·B MovsasL R Coia
May 10, 2000·International Journal of Radiation Oncology, Biology, Physics·G H MannaertsH J Rutten
Aug 1, 1997·Hematology/oncology Clinics of North America·B D Minsky
Oct 17, 1998·Surgical Oncology·A Mahadevan, D Carey
Jul 8, 2000·Surgical Oncology·C S LimJ R Monson
Aug 10, 1999·Critical Reviews in Oncology/hematology·D M Tait
Feb 10, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S G LarsenK-E Giercksky
Jan 19, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marco H M JanssenGuido Lammering
Sep 1, 1996·Acta Radiologica·M B NielsenJ Christiansen
Oct 3, 2001·International Journal of Cancer. Journal International Du Cancer·M El-MaltP Pattyn
Apr 14, 1999·The British Journal of Surgery·M DahlbergL Påhlman
Jun 1, 1997·The British Journal of Surgery·R FaroukL L Gunderson
Sep 1, 1992·World Journal of Surgery·L Påhlman, B Glimelius
Jul 25, 2006·Current Problems in Surgery·Christopher A GarcesWilliam G Cance

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.